Samsn1 SAM domain, SH3 domain and nuclear localization signals, 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Samsn1provided by RGD
Official Full Name: SAM domain, SH3 domain and nuclear localization signals, 1provided by RGD
Primary source: RGD:620926
See related: EnsemblRapid:ENSRNOG00000030930 AllianceGenome:RGD:620926
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nash
Summary: Predicted to enable phosphotyrosine residue binding activity. Predicted to be involved in several processes, including negative regulation of B cell activation; negative regulation of adaptive immune response; and negative regulation of peptidyl-tyrosine phosphorylation. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Orthologous to human SAMSN1 (SAM domain, SH3 domain and nuclear localization signals 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 129.8), Lung (RPKM 74.7) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11p11

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (27971565..28021944, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (14484523..14534900, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (14252088..14405825, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphotyrosine residue binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphotyrosine residue binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of B cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of B cell activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of adaptive immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: SAM domain-containing protein SAMSN-1

Names: SAM domain, SH3 domain and nuclear localisation signals, 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130821.2 → NP_570834.2 SAM domain-containing protein SAMSN-1

See identical proteins and their annotated locations for NP_570834.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

A0A0G2K960, A6JL18, G3V993

Related

ENSRNOP00000074870.1, ENSRNOT00000082143.3

Conserved Domains (4) summary

cd09561
Location:239 → 304

SAM_SAMSN1; SAM domain of SAMSN1 subfamily

smart00454
Location:243 → 304

SAM; Sterile alpha motif

pfam12485
Location:17 → 164

SLY; Lymphocyte signaling adaptor protein

cl17036
Location:167 → 218

SH3; Src Homology 3 domain superfamily