Dkk3 dickkopf WNT signaling pathway inhibitor 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dkk3provided by RGD
Official Full Name: dickkopf WNT signaling pathway inhibitor 3provided by RGD
Primary source: RGD:621846
See related: EnsemblRapid:ENSRNOG00000016343 AllianceGenome:RGD:621846
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: p29; Reic
Summary: Predicted to enable co-receptor binding activity and receptor antagonist activity. Predicted to be involved in several processes, including adrenal gland development; negative regulation of canonical Wnt signaling pathway; and negative regulation of steroid hormone biosynthetic process. Predicted to be active in extracellular space. Orthologous to human DKK3 (dickkopf WNT signaling pathway inhibitor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 377.4), Brain (RPKM 198.2) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q33

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (175672834..175715867, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (166237969..166281271, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (176940424..176983076, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of Dickkopf-3 in Blood Pressure Regulation in Mice and Hypertensive Rats.
Title: Role of Dickkopf-3 in Blood Pressure Regulation in Mice and Hypertensive Rats.
DKK3 ameliorates neuropathic pain via inhibiting ASK-1/JNK/p-38-mediated microglia polarization and neuroinflammation.
Title: DKK3 ameliorates neuropathic pain via inhibiting ASK-1/JNK/p-38-mediated microglia polarization and neuroinflammation.
DKK3 expression negatively regulates the osteogenic differentiation of dental follicle cells.
Title: Dickkopf-related protein 3 negatively regulates the osteogenic differentiation of rat dental follicle cells.
WNT7A can specifically act via a Frizzled-5.LRP6 receptor complex in PC12 cells and that this activity can be antagonized by Dickkopf-1 and Dickkopf-3.
Title: Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins.
data do not support that thyroxine-binding protein p29 has a functional relationship with D2, but expression of p29 in the blood-CSF barrier suggests that it might be involved in T(4) transport to and from the CSF
Title: Divergent expression of type 2 deiodinase and the putative thyroxine-binding protein p29, in rat brain, suggests that they are functionally unrelated proteins.

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General gene information

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Markers

BF404521 (e-PCR)
- UniSTS:261379

RH129863 (e-PCR)
- UniSTS:213151

RH137466 (e-PCR)
- UniSTS:219554

RH140377 (e-PCR)
- UniSTS:222453

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables co-receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables receptor antagonist activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adrenal gland development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of aldosterone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cortisol biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dickkopf-related protein 3

Names: dickkopf 3 homolog; dickkopf homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138519.2 → NP_612528.2 dickkopf-related protein 3 precursor

See identical proteins and their annotated locations for NP_612528.2

Status: VALIDATED

Source sequence(s)

BC160821, JAXUCZ010000001

UniProtKB/TrEMBL

A6I857, B1H219, F7F7Y6

Related

ENSRNOP00000022301.5, ENSRNOT00000022301.8

Conserved Domains (2) summary

pfam06607
Location:208 → 273

Prokineticin; Prokineticin

pfam04706
Location:147 → 196

Dickkopf_N; Dickkopf N-terminal cysteine-rich region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

175672834..175715867 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006230009.5 → XP_006230071.1 dickkopf-related protein 3 isoform X1

See identical proteins and their annotated locations for XP_006230071.1

UniProtKB/TrEMBL

A6I857, B1H219, F7F7Y6

Conserved Domains (2) summary

pfam06607
Location:208 → 273

Prokineticin; Prokineticin

pfam04706
Location:147 → 196

Dickkopf_N; Dickkopf N-terminal cysteine-rich region
XM_017588739.3 → XP_017444228.1 dickkopf-related protein 3 isoform X1

UniProtKB/TrEMBL

A6I857, B1H219, F7F7Y6

Conserved Domains (2) summary

pfam06607
Location:208 → 273

Prokineticin; Prokineticin

pfam04706
Location:147 → 196

Dickkopf_N; Dickkopf N-terminal cysteine-rich region