Hmmr hyaluronan-mediated motility receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hmmrprovided by RGD
Official Full Name: hyaluronan-mediated motility receptorprovided by RGD
Primary source: RGD:2805
See related: EnsemblRapid:ENSRNOG00000059894 AllianceGenome:RGD:2805
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RHAMM
Summary: Predicted to enable cargo receptor activity. Predicted to be involved in hyaluronan catabolic process and receptor-mediated endocytosis. Predicted to be located in centrosome; cytosol; and spindle. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human HMMR (hyaluronan mediated motility receptor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 132.6), Spleen (RPKM 101.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (25635249..25665389, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (25132933..25163029, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (25861490..25890639, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Blocking RHAMM function by peptide injection or topical application is a novel and minimally invasive method for potentially promoting subcutaneous adipogenesis in lipodystrophic diseases and a complementary tool to subcutaneous fat augmentation techniques.
Title: Receptor for hyaluronan mediated motility (RHAMM/HMMR) is a novel target for promoting subcutaneous adipogenesis.
RHAMM mRNA increased over the course of bladder regeneration.
Title: Temporal expression of hyaluronic acid and hyaluronic acid receptors in a porcine small intestinal submucosa-augmented rat bladder regeneration model.
RHAMM and hyaluronic acid mediate smooth muscle cell interactions with collagen and changes in SMC shape, polarity, and movement.
Title: Loss of the hyaluronan receptor RHAMM prevents constrictive artery wall remodeling.
Both ARPC5 and RHAMM, in addition to PKC, were required for migration of neointimal smooth muscle cells.
Title: Rear polarization of the microtubule-organizing center in neointimal smooth muscle cells depends on PKCα, ARPC5, and RHAMM.
The interaction of RHAMM with hyaluronic acid is a critical component of the recruitment of inflammatory cells to the lung after injury.
Title: Expression and role of the hyaluronan receptor RHAMM in inflammation after bleomycin injury.

Submit: New GeneRIF Correction

General gene information

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Markers

UniSTS:236554 (e-PCR)
- UniSTS:236554

AU048333 (e-PCR)
- UniSTS:109639

RH94632 (e-PCR)
- UniSTS:119879

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cargo receptor activity	ISO Inferred from Sequence Orthology more info
enables hyaluronic acid binding	IEA Inferred from Electronic Annotation more info
enables hyaluronic acid binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cell-cell signaling	NAS Non-traceable Author Statement more info	PubMed
involved_in cytoskeleton organization	NAS Non-traceable Author Statement more info	PubMed
involved_in hyaluronan catabolic process	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in spindle	IEA Inferred from Electronic Annotation more info
located_in spindle	ISO Inferred from Sequence Orthology more info
located_in spindle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: hyaluronan-mediated motility receptor

Names: intracellular hyaluronic acid-binding protein; receptor for hyaluronan-mediated motility

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001430107.1 → NP_001417036.1 hyaluronan-mediated motility receptor isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010
NM_012964.3 → NP_037096.3 hyaluronan-mediated motility receptor isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I6A3Z3

Related

ENSRNOP00000070444.3, ENSRNOT00000085499.3

RNA

NR_190859.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

25635249..25665389 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085276.2 → XP_038941204.1 hyaluronan-mediated motility receptor isoform X1

Conserved Domains (3) summary

COG1196
Location:221 → 555

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam15905
Location:16 → 336

HMMR_N; Hyaluronan mediated motility receptor N-terminal

pfam15908
Location:551 → 707

HMMR_C; Hyaluronan mediated motility receptor C-terminal
XM_039085278.2 → XP_038941206.1 hyaluronan-mediated motility receptor isoform X2

Related

ENSRNOP00000104820.1, ENSRNOT00000137152.1

Conserved Domains (3) summary

COG1196
Location:38 → 372

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam15905
Location:1 → 153

HMMR_N; Hyaluronan mediated motility receptor N-terminal

pfam15908
Location:368 → 524

HMMR_C; Hyaluronan mediated motility receptor C-terminal