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    Dock9 dedicator of cytokinesis 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 259237, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dock9provided by RGD
    Official Full Name
    dedicator of cytokinesis 9provided by RGD
    Primary source
    RGD:629617
    See related
    EnsemblRapid:ENSRNOG00000011969 AllianceGenome:RGD:629617
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Trg
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in positive regulation of GTPase activity. Predicted to be located in endomembrane system and membrane. Orthologous to human DOCK9 (dedicator of cytokinesis 9). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 265.2), Heart (RPKM 173.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dock9 in Genome Data Viewer
    Location:
    15q24-q25
    Exon count:
    60
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (105018341..105289799, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (98611518..98883306, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (107945664..108210967, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097091 Neighboring gene solute carrier family 15 member 1 Neighboring gene long non-coding RNA 004 Neighboring gene uncharacterized LOC120097092 Neighboring gene uncharacterized LOC134482163 Neighboring gene UBA domain containing 2 Neighboring gene G protein-coupled receptor 18 Neighboring gene G protein-coupled receptor 183

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes. Nishikimi A, et al. FEBS Lett, 2005 Feb 14. PMID 15710388
    2. The RhoGEF DOCK10 is essential for dendritic spine morphogenesis. Jaudon F, et al. Mol Biol Cell, 2015 Jun 1. PMID 25851601, Free PMC Article
    3. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, et al. Genome Res, 2004 Apr. PMID 15060019, Free PMC Article
    4. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
    5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dedicator of cytokinesis protein 9
    Names
    Thyroid regulating
    cdc42 guanine nucleotide exchange factor zizimin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105759.2 → NP_001099229.2  dedicator of cytokinesis protein 9

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A0G2K2I6
      Related
      ENSRNOP00000059221.4, ENSRNOT00000064705.5
      Conserved Domains (5) summary
      cd08697
      Location:636 → 825
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1600 → 2014
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:169 → 292
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:174 → 279
      PH; PH domain
      pfam11878
      Location:62 → 153
      DUF3398; Domain of unknown function (DUF3398)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      105018341..105289799 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274005.1 → XP_063130075.1  dedicator of cytokinesis protein 9 isoform X9

    2. XM_063274027.1 → XP_063130097.1  dedicator of cytokinesis protein 9 isoform X36

    3. XM_063274015.1 → XP_063130085.1  dedicator of cytokinesis protein 9 isoform X21

    4. XM_006252503.5 → XP_006252565.1  dedicator of cytokinesis protein 9 isoform X30

      UniProtKB/TrEMBL
      A0A8I6AI76, F1LSM8
      Conserved Domains (5) summary
      cd08697
      Location:636 → 825
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1632 → 2046
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:169 → 292
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:174 → 279
      PH; PH domain
      pfam11878
      Location:62 → 153
      DUF3398; Domain of unknown function (DUF3398)

    5. XM_063274004.1 → XP_063130074.1  dedicator of cytokinesis protein 9 isoform X8

    6. XM_063274003.1 → XP_063130073.1  dedicator of cytokinesis protein 9 isoform X6

    7. XM_063273999.1 → XP_063130069.1  dedicator of cytokinesis protein 9 isoform X3

    8. XM_039093014.2 → XP_038948942.1  dedicator of cytokinesis protein 9 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AVS7
      Conserved Domains (4) summary
      cd08697
      Location:648 → 837
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1645 → 2097
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:181 → 304
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:57 → 167
      DUF3398; Domain of unknown function (DUF3398)

    9. XM_063274008.1 → XP_063130078.1  dedicator of cytokinesis protein 9 isoform X13

    10. XM_063274010.1 → XP_063130080.1  dedicator of cytokinesis protein 9 isoform X15

    11. XM_063274013.1 → XP_063130083.1  dedicator of cytokinesis protein 9 isoform X19

    12. XM_063274000.1 → XP_063130070.1  dedicator of cytokinesis protein 9 isoform X4

    13. XM_039093015.2 → XP_038948943.1  dedicator of cytokinesis protein 9 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AVS7
      Conserved Domains (4) summary
      cd08697
      Location:648 → 837
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1644 → 2096
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:181 → 304
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:57 → 167
      DUF3398; Domain of unknown function (DUF3398)

    14. XM_063274014.1 → XP_063130084.1  dedicator of cytokinesis protein 9 isoform X20

    15. XM_063274012.1 → XP_063130082.1  dedicator of cytokinesis protein 9 isoform X16

    16. XM_006252488.5 → XP_006252550.1  dedicator of cytokinesis protein 9 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AI76
      Conserved Domains (5) summary
      cd08697
      Location:648 → 837
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1645 → 2085
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:181 → 304
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:186 → 291
      PH; PH domain
      pfam11878
      Location:74 → 165
      DUF3398; Domain of unknown function (DUF3398)

    17. XM_063274009.1 → XP_063130079.1  dedicator of cytokinesis protein 9 isoform X14

      Related
      ENSRNOP00000092524.2, ENSRNOT00000115819.2

    18. XM_039093024.2 → XP_038948952.1  dedicator of cytokinesis protein 9 isoform X17

      UniProtKB/TrEMBL
      A0A8I6AVS7
      Conserved Domains (4) summary
      cd08697
      Location:648 → 837
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1644 → 2070
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:181 → 304
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:57 → 167
      DUF3398; Domain of unknown function (DUF3398)

    19. XM_039093020.2 → XP_038948948.1  dedicator of cytokinesis protein 9 isoform X7

      UniProtKB/TrEMBL
      A0A8I6AI76
      Conserved Domains (4) summary
      cd08697
      Location:648 → 837
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1644 → 2084
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:181 → 304
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:57 → 167
      DUF3398; Domain of unknown function (DUF3398)

    20. XM_063274021.1 → XP_063130091.1  dedicator of cytokinesis protein 9 isoform X28

    21. XM_006252499.5 → XP_006252561.1  dedicator of cytokinesis protein 9 isoform X22

      UniProtKB/TrEMBL
      A0A8I6AI76
      Conserved Domains (5) summary
      cd08697
      Location:648 → 837
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1645 → 2059
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:181 → 304
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:186 → 291
      PH; PH domain
      pfam11878
      Location:74 → 165
      DUF3398; Domain of unknown function (DUF3398)

    22. XM_063274022.1 → XP_063130092.1  dedicator of cytokinesis protein 9 isoform X29

      Related
      ENSRNOP00000090448.2, ENSRNOT00000108924.2

    23. XM_063274016.1 → XP_063130086.1  dedicator of cytokinesis protein 9 isoform X24

    24. XM_063274023.1 → XP_063130093.1  dedicator of cytokinesis protein 9 isoform X31

    25. XM_039093029.2 → XP_038948957.1  dedicator of cytokinesis protein 9 isoform X34

      UniProtKB/TrEMBL
      A0A8I6AVS7
      Conserved Domains (4) summary
      cd08697
      Location:648 → 837
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1613 → 2039
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:181 → 304
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:57 → 167
      DUF3398; Domain of unknown function (DUF3398)

    26. XM_008770967.4 → XP_008769189.1  dedicator of cytokinesis protein 9 isoform X23

      UniProtKB/TrEMBL
      A0A8I6AI76
      Conserved Domains (5) summary
      cd08697
      Location:648 → 837
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1644 → 2058
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:181 → 304
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:186 → 291
      PH; PH domain
      pfam11878
      Location:74 → 165
      DUF3398; Domain of unknown function (DUF3398)

    27. XM_063274017.1 → XP_063130087.1  dedicator of cytokinesis protein 9 isoform X25

      Related
      ENSRNOP00000093790.1, ENSRNOT00000111187.2

    28. XM_039093030.2 → XP_038948958.1  dedicator of cytokinesis protein 9 isoform X37

      UniProtKB/TrEMBL
      A0A8I6AI76
      Conserved Domains (4) summary
      cd08697
      Location:648 → 837
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1613 → 2027
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:181 → 304
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:57 → 167
      DUF3398; Domain of unknown function (DUF3398)

    29. XM_063274020.1 → XP_063130090.1  dedicator of cytokinesis protein 9 isoform X27

    30. XM_063274007.1 → XP_063130077.1  dedicator of cytokinesis protein 9 isoform X12

    31. XM_063274031.1 → XP_063130101.1  dedicator of cytokinesis protein 9 isoform X46

      Related
      ENSRNOP00000072256.2, ENSRNOT00000090572.3

    32. XM_039093035.2 → XP_038948963.1  dedicator of cytokinesis protein 9 isoform X11

      UniProtKB/TrEMBL
      A0A0G2K2I6
      Conserved Domains (4) summary
      cd08697
      Location:634 → 823
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1630 → 2082
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:167 → 290
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:43 → 153
      DUF3398; Domain of unknown function (DUF3398)

    33. XM_063274006.1 → XP_063130076.1  dedicator of cytokinesis protein 9 isoform X10

    34. XM_063274028.1 → XP_063130098.1  dedicator of cytokinesis protein 9 isoform X39

    35. XM_063274025.1 → XP_063130095.1  dedicator of cytokinesis protein 9 isoform X35

      Related
      ENSRNOP00000078091.2, ENSRNOT00000106361.2

    36. XM_063274019.1 → XP_063130089.1  dedicator of cytokinesis protein 9 isoform X26

    37. XM_006252493.5 → XP_006252555.1  dedicator of cytokinesis protein 9 isoform X18

      UniProtKB/TrEMBL
      A0A0G2K2I6, A0A8I6AKR0
      Conserved Domains (5) summary
      cd08697
      Location:634 → 823
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1629 → 2069
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:167 → 290
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:172 → 277
      PH; PH domain
      pfam11878
      Location:60 → 151
      DUF3398; Domain of unknown function (DUF3398)

    38. XM_039093039.2 → XP_038948967.1  dedicator of cytokinesis protein 9 isoform X38

      UniProtKB/TrEMBL
      A0A0G2K2I6, A0A8I5Y2D8
      Conserved Domains (4) summary
      cd08697
      Location:634 → 823
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1599 → 2013
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:167 → 290
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:43 → 153
      DUF3398; Domain of unknown function (DUF3398)

    39. XM_039093038.2 → XP_038948966.1  dedicator of cytokinesis protein 9 isoform X45

      UniProtKB/TrEMBL
      A0A0G2K2I6
      Conserved Domains (4) summary
      cd08697
      Location:634 → 823
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1599 → 2025
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:167 → 290
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:43 → 153
      DUF3398; Domain of unknown function (DUF3398)

    40. XM_063274024.1 → XP_063130094.1  dedicator of cytokinesis protein 9 isoform X33

    41. XM_017599601.3 → XP_017455090.1  dedicator of cytokinesis protein 9 isoform X32

      UniProtKB/TrEMBL
      A0A0G2K2I6, A0A8I6AN54

    42. XM_039093037.2 → XP_038948965.1  dedicator of cytokinesis protein 9 isoform X44

      UniProtKB/TrEMBL
      A0A0G2K2I6
      Related
      ENSRNOP00000107857.1, ENSRNOT00000168134.1
      Conserved Domains (4) summary
      cd08697
      Location:634 → 823
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1630 → 2056
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:167 → 290
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:43 → 153
      DUF3398; Domain of unknown function (DUF3398)

    43. XM_039093036.2 → XP_038948964.1  dedicator of cytokinesis protein 9 isoform X43

      UniProtKB/TrEMBL
      A0A0G2K2I6
      Related
      ENSRNOP00000093617.2, ENSRNOT00000094084.2
      Conserved Domains (4) summary
      cd08697
      Location:634 → 823
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11698
      Location:1630 → 2070
      DHR2_DOCK9; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 9
      cd13267
      Location:167 → 290
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:43 → 153
      DUF3398; Domain of unknown function (DUF3398)

    44. XM_063274029.1 → XP_063130099.1  dedicator of cytokinesis protein 9 isoform X42

    45. XM_039093031.2 → XP_038948959.1  dedicator of cytokinesis protein 9 isoform X40

      Conserved Domains (3) summary
      cd08697
      Location:648 → 837
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd13267
      Location:181 → 304
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:57 → 167
      DUF3398; Domain of unknown function (DUF3398)

    46. XM_039093033.2 → XP_038948961.1  dedicator of cytokinesis protein 9 isoform X41

      Conserved Domains (3) summary
      cd08697
      Location:648 → 837
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd13267
      Location:181 → 304
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:57 → 167
      DUF3398; Domain of unknown function (DUF3398)

    RNA

    1. XR_010057802.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63603.2 GenPept UniProtKB/Swiss-Prot:Q63603

    Gene LinkOut

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