Sec61a1 SEC61 translocon subunit alpha 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sec61a1provided by RGD
Official Full Name: SEC61 translocon subunit alpha 1provided by RGD
Primary source: RGD:68321
See related: EnsemblRapid:ENSRNOG00000013743 AllianceGenome:RGD:68321
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sec61a
Summary: Predicted to enable several functions, including calcium channel activity; protein transmembrane transporter activity; and ribosome binding activity. Involved in response to type II interferon. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of Sec61 translocon complex. Human ortholog(s) of this gene implicated in common variable immunodeficiency; familial juvenile hyperuricemic nephropathy; and severe congenital neutropenia. Orthologous to human SEC61A1 (SEC61 translocon subunit alpha 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 944.4), Kidney (RPKM 438.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (122530785..122545141, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (120973519..120987871, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (120453577..120467932, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables calcium channel activity	ISO Inferred from Sequence Orthology more info
enables calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribosome binding	IEA Inferred from Electronic Annotation more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info
enables ribosome binding	ISS Inferred from Sequence or Structural Similarity more info
enables signal sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within SRP-dependent cotranslational protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in cotranslational protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in cotranslational protein targeting to membrane	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within endoplasmic reticulum organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-translational protein targeting to endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
involved_in post-translational protein targeting to membrane, translocation	IBA Inferred from Biological aspect of Ancestor more info
involved_in post-translational protein targeting to membrane, translocation	IEA Inferred from Electronic Annotation more info
involved_in post-translational protein targeting to membrane, translocation	ISO Inferred from Sequence Orthology more info
involved_in post-translational protein targeting to membrane, translocation	ISS Inferred from Sequence or Structural Similarity more info
involved_in pronephric nephron development	IEA Inferred from Electronic Annotation more info
involved_in pronephric nephron development	ISO Inferred from Sequence Orthology more info
involved_in pronephric nephron development	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein insertion into ER membrane	IEA Inferred from Electronic Annotation more info
involved_in protein insertion into ER membrane	ISO Inferred from Sequence Orthology more info
involved_in protein insertion into ER membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein targeting to ER	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in response to type II interferon	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of Sec61 translocon complex	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein transport protein Sec61 subunit alpha isoform 1

Names: SEC61, alpha subunit; Sec61 alpha 1 subunit; Sec61 alpha subunit homolog; Sec61 translocon alpha 1 subunit; protein transport protein Sec61 subunit alpha; sec61 alpha-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.