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    Tmt1a thiol methyltransferase 1A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315306, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tmt1aprovided by RGD
    Official Full Name
    thiol methyltransferase 1Aprovided by RGD
    Primary source
    RGD:1308407
    See related
    EnsemblRapid:ENSRNOG00000001376 AllianceGenome:RGD:1308407
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mettl7a; RGD1308407
    Summary
    Predicted to enable mRNA m(6)A methyltransferase activity and thiol S-methyltransferase activity. Predicted to be involved in lncRNA processing; odontogenesis; and osteoblast differentiation. Predicted to be located in endoplasmic reticulum and lipid droplet. Orthologous to human TMT1A (thiol methyltransferase 1A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 1048.4), Uterus (RPKM 218.4) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmt1a in Genome Data Viewer
    Location:
    7q36
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (133330141..133377172)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (131452099..131460154)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (141973447..142021344)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene transmembrane serine protease 12 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134479577 Neighboring gene HIG1 hypoxia inducible domain family, member 1C Neighboring gene solute carrier family 11 member 2 Neighboring gene uncharacterized LOC120093735 Neighboring gene LETM1 domain containing 1 Neighboring gene cysteine and serine rich nuclear protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124657, MGC125112

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA m(6)A methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiol S-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in lncRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in odontogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    methyltransferase-like protein 7A
    Names
    methyltransferase like 7A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037355.2 → NP_001032432.1  methyltransferase-like protein 7A

      See identical proteins and their annotated locations for NP_001032432.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A9K3Y7R7, F1MA49, Q3KRE2
      Related
      ENSRNOP00000086147.2, ENSRNOT00000114081.2
      Conserved Domains (1) summary
      pfam08241
      Location:75 → 172
      Methyltransf_11; Methyltransferase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      133330141..133377172
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263674.1 → XP_063119744.1  methyltransferase-like protein 7A isoform X3

    2. XM_039079337.2 → XP_038935265.1  methyltransferase-like protein 7A isoform X1

      UniProtKB/TrEMBL
      A0A8I6A343
      Conserved Domains (1) summary
      pfam08241
      Location:75 → 166
      Methyltransf_11; Methyltransferase domain

    3. XM_039079338.2 → XP_038935266.1  methyltransferase-like protein 7A isoform X2

      Conserved Domains (1) summary
      pfam08241
      Location:75 → 166
      Methyltransf_11; Methyltransferase domain
    Nucleotide Protein Strain
    Heading Accession and Version

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