Ano6 anoctamin 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ano6provided by RGD
Official Full Name: anoctamin 6provided by RGD
Primary source: RGD:1304765
See related: EnsemblRapid:ENSRNOG00000006995 AllianceGenome:RGD:1304765
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tmem16f
Summary: Predicted to enable monoatomic ion channel activity; phospholipid scramblase activity; and protein homodimerization activity. Involved in positive regulation of potassium ion export across plasma membrane. Predicted to be located in cytosol. Predicted to be part of chloride channel complex. Predicted to be active in cholinergic synapse and synaptic membrane. Human ortholog(s) of this gene implicated in Scott syndrome; ankylosing spondylitis; and inflammatory bowel disease. Orthologous to human ANO6 (anoctamin 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 201.5), Lung (RPKM 183.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q35

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (128812842..128992805)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (126933919..127113588)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (137142063..137335208)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TMEM16F Aggravates Neuronal Loss by Mediating Microglial Phagocytosis of Neurons in a Rat Experimental Cerebral Ischemia and Reperfusion Model.
Title: TMEM16F Aggravates Neuronal Loss by Mediating Microglial Phagocytosis of Neurons in a Rat Experimental Cerebral Ischemia and Reperfusion Model.

Submit: New GeneRIF Correction

General gene information

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Markers

RH130346 (e-PCR)
- UniSTS:213630

BM387481 (e-PCR)
- UniSTS:261534

D7RAT4 (e-PCR)
- UniSTS:120521

BE108488 (e-PCR)
- UniSTS:247775

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium-activated cation channel activity	ISO Inferred from Sequence Orthology more info
enables chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
NOT enables intracellularly calcium-gated chloride channel activity	ISO Inferred from Sequence Orthology more info
enables intracellularly calcium-gated chloride channel activity	ISO Inferred from Sequence Orthology more info
enables phospholipid scramblase activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated chloride channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of blood coagulation via clotting cascade	ISO Inferred from Sequence Orthology more info
involved_in bleb assembly	ISO Inferred from Sequence Orthology more info
involved_in blood coagulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bone mineralization involved in bone maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium activated galactosylceramide scrambling	ISO Inferred from Sequence Orthology more info
involved_in calcium activated phosphatidylcholine scrambling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcium activated phosphatidylcholine scrambling	ISO Inferred from Sequence Orthology more info
involved_in calcium activated phosphatidylserine scrambling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcium activated phosphatidylserine scrambling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium activated phospholipid scrambling	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chloride transport	ISO Inferred from Sequence Orthology more info
involved_in chloride transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dendritic cell chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell volume	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within phosphatidylserine exposure on apoptotic cell surface	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylserine exposure on blood platelet	ISO Inferred from Sequence Orthology more info
involved_in phospholipid translocation	ISO Inferred from Sequence Orthology more info
involved_in plasma membrane phospholipid scrambling	ISO Inferred from Sequence Orthology more info
involved_in pore complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monoatomic ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis, engulfment	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of potassium ion export across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in purinergic nucleotide receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of chloride channel complex	ISO Inferred from Sequence Orthology more info
is_active_in cholinergic synapse	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in synaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: anoctamin-6

Names: transmembrane protein 16F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401001.1 → NP_001387930.1 anoctamin-6

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8I5ZRU7, A0A8I6G530

Related

ENSRNOP00000092185.1, ENSRNOT00000100449.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

128812842..128992805

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008765735.4 → XP_008763957.1 anoctamin-6 isoform X1

UniProtKB/TrEMBL

A0A8I6AA94, A0A8I6G530

Related

ENSRNOP00000089627.1, ENSRNOT00000098138.2

Conserved Domains (2) summary

pfam04547
Location:309 → 893

Anoctamin; Calcium-activated chloride channel

pfam16178
Location:84 → 306

Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin
XM_039079320.2 → XP_038935248.1 anoctamin-6 isoform X4

UniProtKB/TrEMBL

A0A0G2K1M7, A0A8I6G530

Conserved Domains (2) summary

pfam04547
Location:286 → 869

Anoctamin; Calcium-activated chloride channel

pfam16178
Location:61 → 283

Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin
XM_039079322.2 → XP_038935250.1 anoctamin-6 isoform X5

UniProtKB/TrEMBL

A0A8I6ASC3, A0A8I6G530

Conserved Domains (2) summary

pfam04547
Location:265 → 848

Anoctamin; Calcium-activated chloride channel

pfam16178
Location:40 → 262

Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin
XM_039079319.2 → XP_038935247.1 anoctamin-6 isoform X3

UniProtKB/TrEMBL

A0A8I6G530

Conserved Domains (2) summary

pfam04547
Location:294 → 877

Anoctamin; Calcium-activated chloride channel

pfam16178
Location:69 → 291

Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin
XM_039079318.2 → XP_038935246.1 anoctamin-6 isoform X2

UniProtKB/TrEMBL

A0A8I5Y1S2, A0A8I6G530

Related

ENSRNOP00000077951.1, ENSRNOT00000110510.2

Conserved Domains (2) summary

pfam04547
Location:301 → 884

Anoctamin; Calcium-activated chloride channel

pfam16178
Location:76 → 298

Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001108108.1: Suppressed sequence

Description

NM_001108108.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.