Nudcd2 NudC domain containing 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nudcd2provided by RGD
Official Full Name: NudC domain containing 2provided by RGD
Primary source: RGD:1307203
See related: EnsemblRapid:ENSRNOG00000060914 AllianceGenome:RGD:1307203
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1307203
Summary: Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be located in cytosol; intercellular bridge; and mitotic spindle. Predicted to be active in cytoplasm. Orthologous to human NUDCD2 (NudC domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 144.8), Testes (RPKM 116.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (25665493..25671010)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (25163247..25168738)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (25890943..25896432)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BE098866 (e-PCR)
- UniSTS:260937

RH138187 (e-PCR)
- UniSTS:220274

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intercellular bridge	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nudC domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009621.2 → NP_001009621.1 nudC domain-containing protein 2

See identical proteins and their annotated locations for NP_001009621.1

Status: VALIDATED

Source sequence(s)

BC088299

UniProtKB/Swiss-Prot

Q5M823

UniProtKB/TrEMBL

A0A8L2R1N7, A6HDK8

Related

ENSRNOP00000069725.3, ENSRNOT00000086814.3

Conserved Domains (1) summary

cd06494
Location:12 → 104

p23_NUDCD2_like; p23-like NUD (nuclear distribution) C-like found in human NUDC domain-containing protein 2 (NUDCD2) and similar proteins. Little is known about the function of the proteins in this subgroup.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

25665493..25671010

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085371.2 → XP_038941299.1 nudC domain-containing protein 2 isoform X1

Conserved Domains (1) summary

cl00175
Location:7 → 48

alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.