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    Sphk2 sphingosine kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308589, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Sphk2provided by RGD
    Official Full Name
    sphingosine kinase 2provided by RGD
    Primary source
    RGD:1307757
    See related
    EnsemblRapid:ENSRNOG00000021032 AllianceGenome:RGD:1307757
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable D-erythro-sphingosine kinase activity; histone binding activity; and sphingosine-1-phosphate receptor activity. Involved in female pregnancy. Predicted to be located in several cellular components, including endoplasmic reticulum; mitochondrial inner membrane; and nucleoplasm. Predicted to be part of nucleosome. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and membrane. Orthologous to human SPHK2 (sphingosine kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 86.5), Adrenal (RPKM 75.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sphk2 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (105317332..105324985, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (96180872..96188592, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101692972..101700604, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene carbonic anhydrase 11 Neighboring gene D-box binding PAR bZIP transcription factor Neighboring gene ribosomal protein L18 Neighboring gene family with sequence similarity 83, member E Neighboring gene sperm acrosome associated 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Hypoxic preconditioning protects cardiomyocytes against hypoxia/reoxygenation-induced cell apoptosis via sphingosine kinase 2 and FAK/AKT pathway. Zhang R, et al. Exp Mol Pathol, 2016 Feb. PMID 26621495
    2. Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720. Kharel Y, et al. J Biol Chem, 2005 Nov 4. PMID 16093248
    3. Neuronal sphingosine kinase 2 subcellular localization is altered in Alzheimer's disease brain. Dominguez G, et al. Acta Neuropathol Commun, 2018 Apr 3. PMID 29615132, Free PMC Article
    4. ATP-independent glucose stimulation of sphingosine kinase in rat pancreatic islets. Mastrandrea LD, et al. J Lipid Res, 2010 Aug. PMID 20371493, Free PMC Article
    5. Signaling pathways involved in sphingosine kinase activation and sphingosine-1-phosphate release in rat myometrium in late pregnancy: role in the induction of cyclooxygenase 2. Serrano-Sanchez M, et al. Endocrinology, 2008 Sep. PMID 18723875

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. hypoxic preconditioning significantly increased SphK2 expression in primary cardiomyocytes
      Title: Hypoxic preconditioning protects cardiomyocytes against hypoxia/reoxygenation-induced cell apoptosis via sphingosine kinase 2 and FAK/AKT pathway.
    2. Glucose-supported beta-cell growth appears to be in part mediated by SPHK activity.
      Title: ATP-independent glucose stimulation of sphingosine kinase in rat pancreatic islets.
    3. S1P modulates spinal nociceptive processing through inhibition of neuronal cAMP synthesis and sphingosine kinase 1, but not sphingosine kinase 2
      Title: Sphingosine 1-phosphate modulates spinal nociceptive processing.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables D-erythro-sphingosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sphingosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sphingosine-1-phosphate receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood vessel development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within brain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to phorbol 13-acetate 12-myristate ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in female pregnancy IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ceramide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytokine production involved in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-13 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mast cell activation involved in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mast cell degranulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of ATP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytochrome-c oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of reactive oxygen species biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sphinganine-1-phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sphingosine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sphingosine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sphingosine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sphingosine-1-phosphate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription initiation-coupled chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sphingosine kinase 2
    NP_001012066.1
    XP_006229147.1
    XP_008757605.1
    XP_038968225.1
    XP_038968232.1
    XP_063118198.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012066.1 → NP_001012066.1  sphingosine kinase 2

      See identical proteins and their annotated locations for NP_001012066.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079120
      UniProtKB/TrEMBL
      A6JB73, F7FEJ8, Q6AYB2
      Related
      ENSRNOP00000028549.4, ENSRNOT00000028549.7
      Conserved Domains (1) summary
      PLN02958
      Location:152 → 607
      PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      105317332..105324985 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229085.4 → XP_006229147.1  sphingosine kinase 2 isoform X1

      See identical proteins and their annotated locations for XP_006229147.1

      UniProtKB/TrEMBL
      A6JB73, F7FEJ8, Q6AYB2
      Conserved Domains (1) summary
      PLN02958
      Location:152 → 607
      PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase

    2. XM_008759383.3 → XP_008757605.1  sphingosine kinase 2 isoform X1

      See identical proteins and their annotated locations for XP_008757605.1

      UniProtKB/TrEMBL
      A6JB73, F7FEJ8, Q6AYB2
      Conserved Domains (1) summary
      PLN02958
      Location:152 → 607
      PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase

    3. XM_039112304.2 → XP_038968232.1  sphingosine kinase 2 isoform X1

      UniProtKB/TrEMBL
      A6JB73, F7FEJ8, Q6AYB2
      Conserved Domains (1) summary
      PLN02958
      Location:152 → 607
      PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase

    4. XM_039112297.2 → XP_038968225.1  sphingosine kinase 2 isoform X1

      UniProtKB/TrEMBL
      A6JB73, F7FEJ8, Q6AYB2
      Conserved Domains (1) summary
      PLN02958
      Location:152 → 607
      PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase

    5. XM_063262128.1 → XP_063118198.1  sphingosine kinase 2 isoform X1

      UniProtKB/TrEMBL
      A6JB73, F7FEJ8, Q6AYB2
    Nucleotide Protein Strain
    Heading Accession and Version

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