Lmnb1 lamin B1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lmnb1provided by RGD
Official Full Name: lamin B1provided by RGD
Primary source: RGD:620522
See related: EnsemblRapid:ENSRNOG00000013774 AllianceGenome:RGD:620522
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable phospholipase binding activity and sequence-specific double-stranded DNA binding activity. Predicted to be a structural constituent of cytoskeleton and structural constituent of nuclear lamina. Involved in several processes, including cellular response to L-glutamate; cellular response to corticosterone stimulus; and response to xenobiotic stimulus. Located in nuclear lamina; nuclear matrix; and nuclear membrane. Human ortholog(s) of this gene implicated in adult-onset autosomal dominant demyelinating leukodystrophy and primary autosomal recessive microcephaly. Orthologous to human LMNB1 (lamin B1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 293.4), Spleen (RPKM 185.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.1

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (52373939..52413284)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (50175861..50215210)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (51785111..51822264)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lamin B1 decline underlies age-related loss of adult hippocampal neurogenesis.
Title: Lamin B1 decline underlies age-related loss of adult hippocampal neurogenesis.
the current research provided direct evidence that LaminB1 was expressed in the developing cochlea and developmentally regulated in cochlear tissues, suggesting a possible role of LaminB1 in cochlear development. the result provided a theoretical basis for further study about the physiological function of LaminB1 in the peripheral auditory system.
Title: Differential Expression of LaminB1 in the Developing Rat Cochlea.
This differential expression pattern of lamin b1 in retinal neurons suggests that they may be involved in cellular differentiation and expression of cell-specific genes in individual retinal neurons.
Title: Nuclear lamins are differentially expressed in retinal neurons of the adult rat retina.
We now show that epitope masking in the nucleus is often responsible for failure to detect emerin and lamins in human, rat and pig tissues.
Title: The apparent absence of lamin B1 and emerin in many tissue nuclei is due to epitope masking.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Lmnb1 (e-PCR), detects polymorphism
- UniSTS:463523

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables phospholipase binding	IEA Inferred from Electronic Annotation more info
enables phospholipase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear lamina	IEA Inferred from Electronic Annotation more info
enables structural constituent of nuclear lamina	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to L-glutamate	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to corticosterone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in nuclear envelope organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear envelope organization	IEA Inferred from Electronic Annotation more info
involved_in nuclear envelope organization	ISO Inferred from Sequence Orthology more info
involved_in nuclear envelope organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in nuclear migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear pore localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in intermediate filament	IEA Inferred from Electronic Annotation more info
located_in lamin filament	IEA Inferred from Electronic Annotation more info
located_in lamin filament	ISO Inferred from Sequence Orthology more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear inner membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear inner membrane	ISO Inferred from Sequence Orthology more info
is_active_in nuclear lamina	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear lamina	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear lamina	IEA Inferred from Electronic Annotation more info
is_active_in nuclear lamina	ISO Inferred from Sequence Orthology more info
located_in nuclear lamina	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear matrix	IEA Inferred from Electronic Annotation more info
located_in nuclear matrix	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear periphery	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lamin-B1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053905.2 → NP_446357.2 lamin-B1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/Swiss-Prot

P70615

UniProtKB/TrEMBL

A6IX67, G3V7U4

Related

ENSRNOP00000019351.3, ENSRNOT00000019351.7

Conserved Domains (2) summary

pfam00038
Location:31 → 387

Filament; Intermediate filament protein

pfam00932
Location:439 → 542

LTD; Lamin Tail Domain