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    Plppr3 phospholipid phosphatase related 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314614, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Plppr3provided by RGD
    Official Full Name
    phospholipid phosphatase related 3provided by RGD
    Primary source
    RGD:727823
    See related
    EnsemblRapid:ENSRNOG00000027940 AllianceGenome:RGD:727823
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lppr3; Prg-2
    Summary
    Predicted to enable phosphatidate phosphatase activity. Predicted to be involved in phospholipid dephosphorylation; phospholipid metabolic process; and signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human PLPPR3 (phospholipid phosphatase related 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 57.8), Kidney (RPKM 11.0) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plppr3 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10481624..10493059)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9831162..9842434)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12652555..12663825)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene complement factor D Neighboring gene elastase, neutrophil expressed Neighboring gene proteinase 3 Neighboring gene polypyrimidine tract binding protein 1 Neighboring gene uncharacterized LOC134479815

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting. Bräuer AU, et al. Nat Neurosci, 2003 Jun. PMID 12730698
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in phospholipid dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid phosphatase-related protein type 3
    Names
    inactive phospholipid phosphatase PLPPR3
    lipid phosphate phosphatase-related protein type 3
    plasticity-related gene 2 protein
    plasticity-related protein PRG-2
    plasticity-related protein PRG-2-like
    NP_853665.2
    XP_063119480.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181634.3 → NP_853665.2  phospholipid phosphatase-related protein type 3

      See identical proteins and their annotated locations for NP_853665.2

      Status: VALIDATED

      Source sequence(s)
      BC167750, JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q7TMB0
      UniProtKB/TrEMBL
      B3DM92, F1LMM6
      Related
      ENSRNOP00000029601.4, ENSRNOT00000031315.8
      Conserved Domains (1) summary
      cd03384
      Location:127 → 276
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      10481624..10493059
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263410.1 → XP_063119480.1  phospholipid phosphatase-related protein type 3 isoform X1

      UniProtKB/Swiss-Prot
      Q7TMB0
      UniProtKB/TrEMBL
      B3DM92, F1LMM6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TMB0.1 GenPept UniProtKB/Swiss-Prot:Q7TMB0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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