F13a1 coagulation factor XIII A1 chain [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: F13a1provided by RGD
Official Full Name: coagulation factor XIII A1 chainprovided by RGD
Primary source: RGD:621495
See related: EnsemblRapid:ENSRNOG00000015957 AllianceGenome:RGD:621495
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: F13a
Summary: Predicted to enable protein-glutamine gamma-glutamyltransferase activity. Predicted to be involved in blood coagulation, fibrin clot formation and peptide cross-linking. Predicted to act upstream of or within blood coagulation. Predicted to be located in cytoplasm and extracellular region. Biomarker of gastric ulcer. Human ortholog(s) of this gene implicated in artery disease (multiple); factor XIII deficiency; priapism; and thrombophilia (multiple). Orthologous to human F13A1 (coagulation factor XIII A chain). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 106.6), Muscle (RPKM 90.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p12

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (28021197..28197960)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (27815723..27992494)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (28504650..28680015)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D17Got41 (e-PCR)
- UniSTS:114246

D17Rat13 (e-PCR)
- UniSTS:119496

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein-glutamine gamma-glutamyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-glutamine gamma-glutamyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-glutamine gamma-glutamyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-glutamine gamma-glutamyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in blood coagulation, fibrin clot formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in blood coagulation, fibrin clot formation	IEA Inferred from Electronic Annotation more info
involved_in blood coagulation, fibrin clot formation	ISO Inferred from Sequence Orthology more info
involved_in blood coagulation, fibrin clot formation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within peptide cross-linking	ISO Inferred from Sequence Orthology more info
involved_in peptide cross-linking	ISO Inferred from Sequence Orthology more info
involved_in peptide cross-linking	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: coagulation factor XIII A chain

Names: coagulation factor XIII, A1 polypeptide; coagulation factor XIII, A1 subunit; coagulation factor XIIIa; protein-glutamine gamma-glutamyltransferase A chain; transglutaminase A chain

NP_067730.2

EC 2.3.2.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021698.2 → NP_067730.2 coagulation factor XIII A chain

See identical proteins and their annotated locations for NP_067730.2

Status: VALIDATED

Source sequence(s)

BF560108, BQ207464, DN931132, DY575207, JAXUCZ010000017, Y12502

UniProtKB/Swiss-Prot

O08619

UniProtKB/TrEMBL

A6J7C8, G3V811

Related

ENSRNOP00000021568.3, ENSRNOT00000021568.6

Conserved Domains (4) summary

smart00460
Location:309 → 400

TGc; Transglutaminase/protease-like homologues

COG1305
Location:280 → 408

YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]

pfam00868
Location:47 → 164

Transglut_N; Transglutaminase family

pfam00927
Location:519 → 623

Transglut_C; Transglutaminase family, C-terminal ig like domain