Kif15 kinesin family member 15 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kif15provided by RGD
Official Full Name: kinesin family member 15provided by RGD
Primary source: RGD:727790
See related: EnsemblRapid:ENSRNOG00000060356 AllianceGenome:RGD:727790
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Knsl7
Summary: Predicted to enable ATP hydrolysis activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Predicted to be involved in centrosome separation; microtubule-based movement; and mitotic spindle assembly. Predicted to be located in spindle pole. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. Orthologous to human KIF15 (kinesin family member 15). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 138.5), Spleen (RPKM 70.0) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (131479340..131550209)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (122601888..122672750)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (132033117..132103528)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KIF15 supports spermatogenesis via its effects on Sertoli cell microtubule, actin, vimentin, and septin cytoskeletons.
Title: KIF15 supports spermatogenesis via its effects on Sertoli cell microtubule, actin, vimentin, and septin cytoskeletons.
kinesin-12 depletion from cultured rat cortical astrocytes decreases cell proliferation but increases migration.
Title: Depletion of kinesin-12, a myosin-IIB-interacting protein, promotes migration of cortical astrocytes.
Kinesin-12 shares functions with kinesin-5 related to microtubule-microtubule interactions, but kinesin-12 has other functions not shared by kinesin-5 that are related to the ability of kinesin-12 to interact with actin.
Title: Kinesin-12, a mitotic microtubule-associated motor protein, impacts axonal growth, navigation, and branching.

Submit: New GeneRIF Correction

General gene information

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Markers

RH138250 (e-PCR)
- UniSTS:220337

RH139081 (e-PCR)
- UniSTS:221167

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables plus-end-directed microtubule motor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in centrosome separation	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in spindle	IEA Inferred from Electronic Annotation more info
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: kinesin-like protein KIF15

Names: kinesin-like 7; kinesin-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181635.2 → NP_853666.1 kinesin-like protein KIF15

See identical proteins and their annotated locations for NP_853666.1

Status: PROVISIONAL

Source sequence(s)

AY291580

UniProtKB/Swiss-Prot

Q7TN17, Q7TSP2

Related

ENSRNOP00000071501.1, ENSRNOT00000089278.3

Conserved Domains (6) summary

smart00129
Location:26 → 370

KISc; Kinesin motor, catalytic domain. ATPase

PRK03918
Location:426 → 970

PRK03918; chromosome segregation protein; Provisional

TIGR02168
Location:704 → 1375

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd01373
Location:25 → 373

KISc_KLP2_like; Kinesin motor domain, KIF15-like subgroup

pfam12711
Location:463 → 551

Kinesin-relat_1; Kinesin motor

pfam15908
Location:1256 → 1385

HMMR_C; Hyaluronan mediated motility receptor C-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

131479340..131550209

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039081674.2 → XP_038937602.1 kinesin-like protein KIF15 isoform X1

UniProtKB/TrEMBL

A0A0G2K0M1, A6I495

Related

ENSRNOP00000084732.1, ENSRNOT00000096660.2

Conserved Domains (3) summary

COG0419
Location:876 → 1396

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:361 → 1126

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01373
Location:25 → 373

KISc_KLP2_like; Kinesin motor domain, KIF15-like subgroup
XM_039081678.2 → XP_038937606.1 kinesin-like protein KIF15 isoform X4

Conserved Domains (2) summary

COG1196
Location:395 → 749

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01373
Location:25 → 373

KISc_KLP2_like; Kinesin motor domain, KIF15-like subgroup
XM_039081679.2 → XP_038937607.1 kinesin-like protein KIF15 isoform X5

Conserved Domains (2) summary

COG1196
Location:395 → 749

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01373
Location:25 → 373

KISc_KLP2_like; Kinesin motor domain, KIF15-like subgroup
XM_039081680.2 → XP_038937608.1 kinesin-like protein KIF15 isoform X6

Conserved Domains (2) summary

COG1196
Location:395 → 749

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01373
Location:25 → 373

KISc_KLP2_like; Kinesin motor domain, KIF15-like subgroup
XM_039081677.2 → XP_038937605.1 kinesin-like protein KIF15 isoform X3

UniProtKB/TrEMBL

A0A0G2K0M1, A6I495

Conserved Domains (3) summary

PTZ00121
Location:816 → 1299

PTZ00121; MAEBL; Provisional

COG1196
Location:264 → 1039

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl22853
Location:1 → 276

Motor_domain; Myosin and Kinesin motor domain
XM_039081675.2 → XP_038937603.1 kinesin-like protein KIF15 isoform X2

UniProtKB/TrEMBL

A0A0G2K0M1, A6I495

Conserved Domains (3) summary

PTZ00121
Location:836 → 1319

PTZ00121; MAEBL; Provisional

COG1196
Location:284 → 1059

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01373
Location:2 → 296

KISc_KLP2_like; Kinesin motor domain, KIF15-like subgroup
XM_039081676.2 → XP_038937604.1 kinesin-like protein KIF15 isoform X2

UniProtKB/TrEMBL

A0A0G2K0M1, A6I495

Conserved Domains (3) summary

PTZ00121
Location:836 → 1319

PTZ00121; MAEBL; Provisional

COG1196
Location:284 → 1059

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01373
Location:2 → 296

KISc_KLP2_like; Kinesin motor domain, KIF15-like subgroup