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    Tmem106a transmembrane protein 106A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287722, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem106aprovided by RGD
    Official Full Name
    transmembrane protein 106Aprovided by RGD
    Primary source
    RGD:1309043
    See related
    EnsemblRapid:ENSRNOG00000023628 AllianceGenome:RGD:1309043
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309043
    Summary
    Predicted to be involved in several processes, including glycoprotein biosynthetic process; positive regulation of intracellular signal transduction; and positive regulation of macromolecule biosynthetic process. Predicted to be located in plasma membrane. Orthologous to human TMEM106A (transmembrane protein 106A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 353.3), Adrenal (RPKM 73.9) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem106a in Genome Data Viewer
    Location:
    10q31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (87007144..87016161)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (86506908..86515915)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (89484269..89493288)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene BRCA1, DNA repair associated Neighboring gene uncharacterized LOC134480878 Neighboring gene NBR1, autophagy cargo receptor Neighboring gene coiled-coil domain containing 200 Neighboring gene BCL2-associated X protein, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transmembrane protein 106a activates mouse peritoneal macrophages via the MAPK and NF-κB signaling pathways. Dai H, et al. Sci Rep, 2015 Jul 28. PMID 26215746, Free PMC Article
    2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108779

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in CD80 biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in CD80 biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in CD86 biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in CD86 biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macrophage activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in macrophage activation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of MHC class II biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of MHC class II biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-1 beta production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-6 production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of nitric oxide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of nitric oxide metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of tumor necrosis factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 106A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024967.1 → NP_001020138.1  transmembrane protein 106A

      See identical proteins and their annotated locations for NP_001020138.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091170
      UniProtKB/Swiss-Prot
      Q5BK83
      UniProtKB/TrEMBL
      A0A8I5ZLV0, A6HJD7
      Conserved Domains (1) summary
      pfam07092
      Location:27 → 251
      DUF1356; Protein of unknown function (DUF1356)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      87007144..87016161
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268744.1 → XP_063124814.1  transmembrane protein 106A isoform X2

      UniProtKB/Swiss-Prot
      Q5BK83
      UniProtKB/TrEMBL
      A0A8I5ZLV0, A6HJD7

    2. XM_008767978.3 → XP_008766200.1  transmembrane protein 106A isoform X1

      See identical proteins and their annotated locations for XP_008766200.1

      UniProtKB/TrEMBL
      A0A8L2UL38
      Conserved Domains (1) summary
      pfam07092
      Location:27 → 221
      DUF1356; Protein of unknown function (DUF1356)

    3. XM_039085622.2 → XP_038941550.1  transmembrane protein 106A isoform X1

      UniProtKB/TrEMBL
      A0A8L2UL38
      Conserved Domains (1) summary
      pfam07092
      Location:27 → 221
      DUF1356; Protein of unknown function (DUF1356)

    4. XM_063268741.1 → XP_063124811.1  transmembrane protein 106A isoform X1

      UniProtKB/TrEMBL
      A0A8L2UL38

    5. XM_063268743.1 → XP_063124813.1  transmembrane protein 106A isoform X2

      UniProtKB/Swiss-Prot
      Q5BK83
      UniProtKB/TrEMBL
      A0A8I5ZLV0, A6HJD7

    6. XM_063268742.1 → XP_063124812.1  transmembrane protein 106A isoform X2

      UniProtKB/Swiss-Prot
      Q5BK83
      UniProtKB/TrEMBL
      A0A8I5ZLV0, A6HJD7
      Related
      ENSRNOP00000036228.6, ENSRNOT00000035523.6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BK83.1 GenPept UniProtKB/Swiss-Prot:Q5BK83

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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