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    Cerk ceramide kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300129, updated on 27-Nov-2024

    Summary

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    Symbol
    Cerkprovided by RGD
    Full Name
    ceramide kinaseprovided by RGD
    Primary source
    RGD:1305019
    See related
    EnsemblRapid:ENSRNOG00000017022 AllianceGenome:RGD:1305019
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ceramide kinase activity and magnesium ion binding activity. Predicted to be involved in ceramide metabolic process. Predicted to be located in plasma membrane. Orthologous to human CERK (ceramide kinase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 241.1), Brain (RPKM 162.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cerk in Genome Data Viewer
    Location:
    7q34
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (119105674..119149885, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (117225855..117269436, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (127015162..127058056, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene cadherin, EGF LAG seven-pass G-type receptor 1 Neighboring gene GRAM domain containing 4 Neighboring gene uncharacterized LOC134479762 Neighboring gene TBC1 domain family, member 22a like Neighboring gene TBC1 domain family, member 22a Neighboring gene U7 small nuclear RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Down-regulation of ceramide kinase via proteasome and lysosome pathways in PC12 cells by serum withdrawal: Its protection by nerve growth factor and role in exocytosis. Hori M, et al. Biochim Biophys Acta Mol Cell Res, 2020 Jul. PMID 32246947
    2. A differential role for ceramide kinase in antigen/FcɛRI-mediated mast cell activation and function. Hewson CA, et al. Clin Exp Allergy, 2011 Mar. PMID 21255156
    3. Ceramide kinase is a mediator of calcium-dependent degranulation in mast cells. Mitsutake S, et al. J Biol Chem, 2004 Apr 23. PMID 14769792
    4. Subcellular localization of ceramide kinase and ceramide kinase-like protein requires interplay of their Pleckstrin Homology domain-containing N-terminal regions together with C-terminal domains. Rovina P, et al. Biochim Biophys Acta, 2009 Oct. PMID 19501188
    5. Wild-type levels of ceramide and ceramide-1-phosphate in the retina of ceramide kinase-like-deficient mice. Graf C, et al. Biochem Biophys Res Commun, 2008 Aug 15. PMID 18555012

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Down-regulation of ceramide kinase via proteasome and lysosome pathways in PC12 cells by serum withdrawal: Its protection by nerve growth factor and role in exocytosis.
      Title: Down-regulation of ceramide kinase via proteasome and lysosome pathways in PC12 cells by serum withdrawal: Its protection by nerve growth factor and role in exocytosis.
    2. We have identified a differential role for ceramide kinase in mast-cell activation
      Title: A differential role for ceramide kinase in antigen/FcɛRI-mediated mast cell activation and function.
    3. Ceramide kinase has a role as a mediator of calcium-dependent degranulation in mast cells.
      Title: Ceramide kinase is a mediator of calcium-dependent degranulation in mast cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ceramide kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ceramide kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ceramide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ceramide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ceramide kinase
    NP_001128333.1
    XP_038934781.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134861.1 → NP_001128333.1  ceramide kinase

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      D3Z9Y3
      Related
      ENSRNOP00000022882.4, ENSRNOT00000022882.7
      Conserved Domains (1) summary
      cl01255
      Location:55 → 528
      DAGK_cat; Diacylglycerol kinase catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      119105674..119149885 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078853.2 → XP_038934781.1  ceramide kinase isoform X1

      Conserved Domains (1) summary
      cl01255
      Location:216 → 505
      DAGK_cat; Diacylglycerol kinase catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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