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    Prpf4b pre-mRNA processing factor 4B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291078, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Prpf4bprovided by RGD
    Official Full Name
    pre-mRNA processing factor 4Bprovided by RGD
    Primary source
    RGD:1307784
    See related
    EnsemblRapid:ENSRNOG00000016705 AllianceGenome:RGD:1307784
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Prp4k
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in positive regulation of protein export from nucleus; regulation of intracellular signal transduction; and spliceosomal tri-snRNP complex assembly. Predicted to be located in kinetochore and nuclear speck. Predicted to be part of catalytic step 2 spliceosome. Predicted to be active in nucleus. Orthologous to human PRP4K (pre-mRNA processing factor kinase PRP4K). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 297.0), Spleen (RPKM 261.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prpf4b in Genome Data Viewer
    Location:
    17p12
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (30190721..30230153, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (29985343..30020285, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (30680454..30714542, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene enoyl-Coenzyme A delta isomerase 3 Neighboring gene testis expressed 56 Neighboring gene family with sequence similarity 217, member A Neighboring gene high mobility group box 1, pseudogene 2 Neighboring gene family with sequence similarity 50, member B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Capturing novel mouse genes encoding chromosomal and other nuclear proteins. Tate P, et al. J Cell Sci, 1998 Sep. PMID 9701556
    2. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. Jurica MS, et al. RNA, 2002 Apr. PMID 11991638, Free PMC Article
    3. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
    4. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
    5. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA cis splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of hippo signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of hippo signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic cell cycle spindle assembly checkpoint IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitotic cell cycle spindle assembly checkpoint ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic cell cycle spindle assembly checkpoint ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spliceosomal snRNP assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spliceosomal snRNP assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spliceosomal tri-snRNP complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spliceosomal tri-snRNP complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spliceosomal tri-snRNP complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase PRP4 homolog
    Names
    PRP4 pre-mRNA processing factor 4 homolog B
    PRP4 pre-mRNA-processing factor 4 homolog
    NP_001011923.1
    XP_038951416.1
    XP_038951417.1
    XP_063132231.1
    XP_063132232.1
    XP_063132233.1
    XP_063132234.1
    XP_063132235.1
    XP_063132236.1
    XP_063132237.1
    XP_063132238.1
    XP_063132239.1
    XP_063132240.1
    XP_063132241.1
    XP_063132242.1
    XP_063132243.1
    XP_063132244.1
    XP_063132245.1
    XP_063132246.1
    XP_063132247.1
    XP_063132248.1
    XP_063132249.1
    XP_063132250.1
    XP_063132251.1
    XP_063132252.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011923.1 → NP_001011923.1  serine/threonine-protein kinase PRP4 homolog

      See identical proteins and their annotated locations for NP_001011923.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085927
      UniProtKB/Swiss-Prot
      Q5RKH1
      UniProtKB/TrEMBL
      A6J7F3
      Related
      ENSRNOP00000072106.2, ENSRNOT00000081993.3
      Conserved Domains (2) summary
      PTZ00108
      Location:171 → 396
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      cd14135
      Location:686 → 1003
      STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      30190721..30230153 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095488.2 → XP_038951416.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q5RKH1
      UniProtKB/TrEMBL
      A6J7F3
      Conserved Domains (2) summary
      PTZ00108
      Location:171 → 396
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      cd14135
      Location:686 → 1003
      STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4

    2. XM_063276166.1 → XP_063132236.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q5RKH1

    3. XM_063276167.1 → XP_063132237.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q5RKH1

    4. XM_063276181.1 → XP_063132251.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q5RKH1

    5. XM_063276180.1 → XP_063132250.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q5RKH1

    6. XM_063276178.1 → XP_063132248.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q5RKH1

    7. XM_063276168.1 → XP_063132238.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q5RKH1

    8. XM_063276162.1 → XP_063132232.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q5RKH1

    9. XM_063276164.1 → XP_063132234.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q5RKH1

    10. XM_063276165.1 → XP_063132235.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q5RKH1

    11. XM_063276163.1 → XP_063132233.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q5RKH1

    12. XM_063276161.1 → XP_063132231.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q5RKH1

    13. XM_063276169.1 → XP_063132239.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q5RKH1

    14. XM_063276179.1 → XP_063132249.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q5RKH1

    15. XM_063276171.1 → XP_063132241.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q5RKH1

    16. XM_063276177.1 → XP_063132247.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q5RKH1

    17. XM_063276170.1 → XP_063132240.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q5RKH1

    18. XM_063276176.1 → XP_063132246.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q5RKH1

    19. XM_063276175.1 → XP_063132245.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q5RKH1

    20. XM_063276174.1 → XP_063132244.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q5RKH1

    21. XM_063276172.1 → XP_063132242.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q5RKH1

    22. XM_063276173.1 → XP_063132243.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q5RKH1

    23. XM_063276182.1 → XP_063132252.1  serine/threonine-protein kinase PRP4 homolog isoform X2

    24. XM_039095489.2 → XP_038951417.1  serine/threonine-protein kinase PRP4 homolog isoform X3

      Conserved Domains (1) summary
      PTZ00108
      Location:171 → 396
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5RKH1.1 GenPept UniProtKB/Swiss-Prot:Q5RKH1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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