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    Slfn2 schlafen family member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303380, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slfn2provided by RGD
    Official Full Name
    schlafen family member 2provided by RGD
    Primary source
    RGD:1308645
    See related
    EnsemblRapid:ENSRNOG00000037113 AllianceGenome:RGD:1308645
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable tRNA binding activity. Predicted to be involved in T cell mediated immunity; T cell proliferation involved in immune response; and tRNA stabilization. Predicted to act upstream of or within negative regulation of cell population proliferation and response to bacterium. Predicted to be active in cytoplasm. Orthologous to human SLFN12L (schlafen family member 12 like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 713.5), Thymus (RPKM 499.7) and 7 other tissues See more
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    Genomic context

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    See Slfn2 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (68450861..68457198)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (67953322..67959659)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (70370381..70376718)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene large ribosomal subunit protein uL18-like Neighboring gene schlafen family member 9 Neighboring gene spindle and kinetochore-associated protein 2 pseudogene Neighboring gene schlafen family member 1 Neighboring gene schlafen family member 4 Neighboring gene glutathione S-transferase, alpha 4 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables tRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell mediated immunity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell proliferation involved in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    schlafen family member 12-like
    Names
    schlafen 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107031.1 → NP_001100501.1  schlafen family member 12-like

      See identical proteins and their annotated locations for NP_001100501.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A0A096MJK8, A6HHF9
      Conserved Domains (2) summary
      pfam04326
      Location:231 → 340
      AlbA_2; Putative DNA-binding domain
      pfam17057
      Location:123 → 231
      B3R; Poxviridae B3 protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      68450861..68457198
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086039.2 → XP_038941967.1  schlafen family member 12-like isoform X1

      UniProtKB/TrEMBL
      A0A096MJK8, D4A2D6
      Related
      ENSRNOP00000052810.3, ENSRNOT00000055957.5
      Conserved Domains (1) summary
      PHA02782
      Location:17 → 339
      PHA02782; hypothetical protein; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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