Abcb8 ATP binding cassette subfamily B member 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abcb8provided by RGD
Official Full Name: ATP binding cassette subfamily B member 8provided by RGD
Primary source: RGD:1307655
See related: EnsemblRapid:ENSRNOG00000008557 AllianceGenome:RGD:1307655
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MITOSUR
Summary: Predicted to enable ABC-type peptide transporter activity and ATP binding activity. Predicted to be involved in cell volume homeostasis and mitochondrial potassium ion transmembrane transport. Predicted to be located in mitochondrial inner membrane; nucleolus; and nucleoplasm. Predicted to be part of mitochondrial ATP-gated potassium channel complex. Predicted to be active in membrane and mitochondrion. Orthologous to human ABCB8 (ATP binding cassette subfamily B member 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 85.6), Heart (RPKM 85.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q11

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (11660716..11676030, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (10766206..10783598, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (7296538..7311856, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results indicate that ABCB8 is essential for normal cardiac function, maintenance of mitochondrial iron homeostasis and maturation of cytosolic Fe/S proteins.
Title: Disruption of ATP-binding cassette B8 in mice leads to cardiomyopathy through a decrease in mitochondrial iron export.
In the testis, rat abcb8 was expressed both in the somatic Sertoli cells and peritubular cells and in the germline (spermatogonia and pachytene spermatocytes).
Title: Molecular cloning of several rat ABC transporters including a new ABC transporter, Abcb8, and their expression in rat testis.

Submit: New GeneRIF Correction

General gene information

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Markers

RH124903 (e-PCR)
- UniSTS:161725

D4Rat250 (e-PCR)
- UniSTS:227793

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell volume homeostasis	IEA Inferred from Electronic Annotation more info
involved_in cell volume homeostasis	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in peptide transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial ATP-gated potassium channel complex	IEA Inferred from Electronic Annotation more info
part_of mitochondrial ATP-gated potassium channel complex	ISO Inferred from Sequence Orthology more info
part_of mitochondrial ATP-gated potassium channel complex	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial potassium channel ATP-binding subunit

Names: ABC transporter 8; ATP-binding cassette sub-family B member 8, mitochondrial; ATP-binding cassette, sub-family B (MDR/TAP), member 8; ATP-binding cassette, sub-family B, member 8; ATP-binding cassette, subfamily B (MDR/TAP), member 8; mitochondrial sulfonylurea-receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007796.2 → NP_001007797.1 mitochondrial potassium channel ATP-binding subunit precursor

See identical proteins and their annotated locations for NP_001007797.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

Q0QVT4, Q5RKI8

UniProtKB/TrEMBL

A0A0H2UHH3

Related

ENSRNOP00000012222.5, ENSRNOT00000012222.8

Conserved Domains (1) summary

COG1132
Location:116 → 695

MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

11660716..11676030 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107751.2 → XP_038963679.1 mitochondrial potassium channel ATP-binding subunit isoform X4

Conserved Domains (1) summary

COG1132
Location:18 → 456

MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
XM_006235946.4 → XP_006236008.1 mitochondrial potassium channel ATP-binding subunit isoform X1

UniProtKB/TrEMBL

A0A0H2UHH3

Conserved Domains (3) summary

cd03249
Location:334 → 572

ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins

COG1132
Location:16 → 575

MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]

pfam00664
Location:16 → 287

ABC_membrane; ABC transporter transmembrane region
XM_039107752.2 → XP_038963680.1 mitochondrial potassium channel ATP-binding subunit isoform X5

Conserved Domains (3) summary

cd03249
Location:188 → 426

ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins

cd07346
Location:7 → 56

ABC_6TM_exporters; TM helix 4 [structural motif]

cl38913
Location:2 → 161

ABC_6TM_exporters; Six-transmembrane helical domain of the ATP-binding cassette transporters
XM_063286229.1 → XP_063142299.1 mitochondrial potassium channel ATP-binding subunit isoform X3
XM_063286228.1 → XP_063142298.1 mitochondrial potassium channel ATP-binding subunit isoform X2