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    Zfp185 zinc finger protein 185 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689949, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp185provided by RGD
    Official Full Name
    zinc finger protein 185provided by RGD
    Primary source
    RGD:1586351
    See related
    EnsemblRapid:ENSRNOG00000051704 AllianceGenome:RGD:1586351
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metal ion binding activity. Orthologous to human ZNF185 (zinc finger protein 185 with LIM domain). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 10.6), Lung (RPKM 8.2) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp185 in Genome Data Viewer
    Location:
    Xq37
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (155874138..155919921)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (150831869..150877652)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (152989099..153034289)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene centrin 2 Neighboring gene NAD(P) dependent steroid dehydrogenase-like Neighboring gene PNMA family member 5 Neighboring gene PNMA family member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. JUNB-FBXO21-ERK axis promotes cartilage degeneration in osteoarthritis by inhibiting autophagy. Lin Z, et al. Aging Cell, 2021 Feb. PMID 33450132, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 185

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433021.1 → NP_001419950.1  zinc finger protein 185 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A0G2JUQ6

    2. NM_001433022.1 → NP_001419951.1  zinc finger protein 185 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A0G2JUQ6

    3. NM_001433023.1 → NP_001419952.1  zinc finger protein 185 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021

    4. NM_001433024.1 → NP_001419953.1  zinc finger protein 185 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I6AH10

    5. NM_001433025.1 → NP_001419954.1  zinc finger protein 185 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      155874138..155919921
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039100265.2 → XP_038956193.1  zinc finger protein 185 isoform X3

      UniProtKB/TrEMBL
      A6KSY8
      Conserved Domains (2) summary
      smart00132
      Location:489 → 545
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
      pfam10479
      Location:363 → 483
      FSA_C; Fragile site-associated protein C-terminus

    2. XM_006229520.5 → XP_006229582.1  zinc finger protein 185 isoform X1

      Related
      ENSRNOP00000069186.2, ENSRNOT00000088234.3
      Conserved Domains (1) summary
      smart00132
      Location:516 → 572
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3

    3. XM_006229522.5 → XP_006229584.1  zinc finger protein 185 isoform X2

      See identical proteins and their annotated locations for XP_006229584.1

      UniProtKB/TrEMBL
      A6KSY8
      Conserved Domains (1) summary
      smart00132
      Location:515 → 571
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3

    4. XM_017602422.3 → XP_017457911.1  zinc finger protein 185 isoform X1

      Conserved Domains (1) summary
      smart00132
      Location:516 → 572
      LIM; Zinc-binding domain present in Lin-11, Isl-1, Mec-3
    Nucleotide Protein Strain
    Heading Accession and Version

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