Cxcl9 C-X-C motif chemokine ligand 9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cxcl9provided by RGD
Official Full Name: C-X-C motif chemokine ligand 9provided by RGD
Primary source: RGD:628798
See related: EnsemblRapid:ENSRNOG00000022242 AllianceGenome:RGD:628798
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mig; Scyb9
Summary: Predicted to enable CXCR3 chemokine receptor binding activity and chemokine activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; neutrophil chemotaxis; and positive regulation of release of sequestered calcium ion into cytosol. Predicted to act upstream of or within several processes, including defense response to virus; positive regulation of myoblast differentiation; and positive regulation of myoblast fusion. Predicted to be located in external side of plasma membrane. Predicted to be active in extracellular space. Orthologous to human CXCL9 (C-X-C motif chemokine ligand 9). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 145.4), Muscle (RPKM 120.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (16007166..16012077)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (15722868..15727779)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (17228832..17233743)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ursolic acid inhibits Th17 cell differentiation via STAT3/RORgammat pathway and suppresses Schwann cell-mediated Th17 cell migration by reducing CXCL9/10 expression.
Title: Ursolic acid inhibits Th17 cell differentiation via STAT3/RORγt pathway and suppresses Schwann cell-mediated Th17 cell migration by reducing CXCL9/10 expression.
Upregulation of lncRNA-NONRATT021203.2 in the dorsal root ganglion contributes to cancer-induced pain via CXCL9 in rats.
Title: Upregulation of lncRNA-NONRATT021203.2 in the dorsal root ganglion contributes to cancer-induced pain via CXCL9 in rats.
results reveal that Cxcl9 is a negative modulator of angiogenesis and osteogenesis, and its inhibition could promote pre-vascularization of bone tissue engineering
Title: Inhibiting expression of Cxcl9 promotes angiogenesis in MSCs-HUVECs co-culture.
CXCL9 is involved in the modulation of pancreatic fibrogenesis in trinitrobenzene sulfonic acid-induced chronic pancreatitis in rats, and may be a therapeutic target in pancreatic fibrosis.
Title: Antifibrotic role of chemokine CXCL9 in experimental chronic pancreatitis induced by trinitrobenzene sulfonic acid in rats.
results suggest that chemokines, including Mig (CXCL9) have neurotrophic effects on the nervous system
Title: Monokine induced by interferon-gamma acts as a neurotrophic factor on PC12 cells and rat primary sympathetic neurons.
has an important role in the recruitment of mononuclear cells, a pivotal event in the pathogenesis of acute lung allograft rejection
Title: Role of CXCL9/CXCR3 chemokine biology during pathogenesis of acute lung allograft rejection.

Submit: New GeneRIF Correction

General gene information

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Markers

AI044222 (e-PCR)
- UniSTS:247955

RH141482 (e-PCR)
- UniSTS:223476

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables CXCR chemokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables CXCR3 chemokine receptor binding	ISO Inferred from Sequence Orthology more info
enables CXCR3 chemokine receptor binding	TAS Traceable Author Statement more info	PubMed
enables chemokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine activity	ISO Inferred from Sequence Orthology more info
enables chemokine activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in induction of positive chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in neutrophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of myoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of myoblast fusion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C-X-C motif chemokine 9

Names: chemokine (C-X-C motif) ligand 9; monokine induced by gamma interferon; small inducible cytokine B9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145672.4 → NP_663705.1 C-X-C motif chemokine 9 precursor

See identical proteins and their annotated locations for NP_663705.1

Status: PROVISIONAL

Source sequence(s)

AF537208

UniProtKB/TrEMBL

A6KK93, F7F001, Q8K4B1

Related

ENSRNOP00000003627.4, ENSRNOT00000003082.9

Conserved Domains (1) summary

cd00273
Location:29 → 89

Chemokine_CXC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif ...