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    Klhl23 kelch-like family member 23 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311114, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Klhl23provided by RGD
    Official Full Name
    kelch-like family member 23provided by RGD
    Primary source
    RGD:1307166
    See related
    EnsemblRapid:ENSRNOG00000007981 AllianceGenome:RGD:1307166
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307166
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KLHL23 (kelch like family member 23). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 146.5), Muscle (RPKM 91.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Klhl23 in Genome Data Viewer
    Location:
    3q21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (74988778..75002347)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (54580788..54594530)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (56056957..56070614)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 210 Neighboring gene phosphatase, orphan 2 Neighboring gene small nucleolar RNA U13 Neighboring gene small RNA binding exonuclease protection factor La Neighboring gene methyltransferase 5, N6-adenosine

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 23
    Names
    kelch-like 23

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134504.2 → NP_001127976.1  kelch-like protein 23 isoform b

      See identical proteins and their annotated locations for NP_001127976.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HM17, D3ZLV9
      Related
      ENSRNOP00000010508.5, ENSRNOT00000010508.7
      Conserved Domains (6) summary
      smart00612
      Location:322 → 369
      Kelch; Kelch domain
      PHA03098
      Location:45 → 545
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:359 → 402
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:33 → 131
      BTB; BTB/POZ domain
      pfam01344
      Location:358 → 402
      Kelch_1; Kelch motif
      pfam07707
      Location:139 → 239
      BACK; BTB And C-terminal Kelch

    2. NM_001431692.1 → NP_001418621.1  kelch-like protein 23 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    3. NM_001431693.1 → NP_001418622.1  kelch-like protein 23 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    4. NM_001431694.1 → NP_001418623.1  kelch-like protein 23 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    5. NM_001431695.1 → NP_001418624.1  kelch-like protein 23 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      74988778..75002347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234314.4 → XP_006234376.1  kelch-like protein 23 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JW57
      Related
      ENSRNOP00000109898.1, ENSRNOT00000128326.1
      Conserved Domains (6) summary
      smart00612
      Location:509 → 557
      Kelch; Kelch domain
      PHA03098
      Location:45 → 545
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:359 → 402
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:33 → 131
      BTB; BTB/POZ domain
      pfam01344
      Location:358 → 402
      Kelch_1; Kelch motif
      pfam07707
      Location:139 → 239
      BACK; BTB And C-terminal Kelch

    2. XM_006234316.5 → XP_006234378.1  kelch-like protein 23 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JW57
      Conserved Domains (6) summary
      smart00612
      Location:509 → 557
      Kelch; Kelch domain
      PHA03098
      Location:45 → 545
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:359 → 402
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:33 → 131
      BTB; BTB/POZ domain
      pfam01344
      Location:358 → 402
      Kelch_1; Kelch motif
      pfam07707
      Location:139 → 239
      BACK; BTB And C-terminal Kelch

    3. XM_006234313.5 → XP_006234375.1  kelch-like protein 23 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JW57
      Related
      ENSRNOP00000069751.2, ENSRNOT00000088351.3
      Conserved Domains (6) summary
      smart00612
      Location:517 → 565
      Kelch; Kelch domain
      PHA03098
      Location:53 → 553
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:367 → 410
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:41 → 139
      BTB; BTB/POZ domain
      pfam01344
      Location:366 → 410
      Kelch_1; Kelch motif
      pfam07707
      Location:147 → 247
      BACK; BTB And C-terminal Kelch
    Nucleotide Protein Strain
    Heading Accession and Version

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