Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp17a1provided by RGD
Official Full Name: cytochrome P450, family 17, subfamily a, polypeptide 1provided by RGD
Primary source: RGD:2456
See related: EnsemblRapid:ENSRNOG00000020035 AllianceGenome:RGD:2456
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cyp17
Summary: Enables steroid 17-alpha-monooxygenase activity. Involved in several processes, including Leydig cell differentiation; response to fungicide; and response to herbicide. Located in cell projection and neuronal cell body. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including cholelithiasis; congenital adrenal hyperplasia; gallbladder cancer; osteoporosis; and prostate cancer. Orthologous to human CYP17A1 (cytochrome P450 family 17 subfamily A member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 292.2), Testes (RPKM 130.7) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (255476861..255484547, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (245535462..245543148, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (266422127..266429947, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that CYP17A1 and aromatase/Cyp19a1 are induced in hippocampus by the environmental pollutant/retinoid X receptor agonist tributyltin; thus, tributyltin appears to stimulate estradiol biosynthesis.
Title: Stimulation of estradiol biosynthesis by tributyltin in rat hippocampal slices.
Data from a rat model of polycystic ovary syndrome suggest that hyperandrogenism develops and this may partially up-regulate expression of steroidogenic enzymes (CYP17 and P450scc [cholesterol side-chain cleavage enzyme]) in ovarian tissue.
Title: Increased expression of P450scc and CYP17 in development of endogenous hyperandrogenism in a rat model of PCOS.
these data demonstrate the occurrence of P450C(17) in the deep cerebellar nuclei of the rat
Title: Cytochrome P450 17α-hydroxylase/C(17,20)-lyase immunoreactivity and molecular expression in the cerebellar nuclei of adult male rats.
Data demonstrate, for the first time, the presence and anatomical distribution of P450C(17) in the vestibular nuclei.
Title: Immunohistochemical localisation and molecular expression of the steroidogenic enzyme cytochrome P450 17α-hydroxylase /C(17,20)-lyase in the vestibular nuclei of adult male rats.
Dibromoacetic acid can directly target rat Leydig cells and downregulate testicular CYP17 expression with a resulting decreased testicular testosterone production.
Title: Role of cytochrome P450c17α in dibromoacetic acid-induced testicular toxicity in rats.
immunolocalization of 3beta-hydroxysteroid dehydrogense, cytochrome P450c17 and androgen receptor were investigated in rat cumuli oophori of late pre-ovulatory follicles and in post-ovulatory COCs bearing fertilized oocytes
Title: Immunolocalization of androgen receptor and steroidogenic enzymes in cumuli oophori of pre- and post-ovulatory rats.
Results suggest that PCB126 may affect testicular steroidogenesis by downregulating P450(17alpha), P450(scc) and have inhibitory effect on the testicular functions.
Title: Polychlorinated biphenyls have inhibitory effect on testicular steroidogenesis by downregulation of P450(17alpha) and P450(scc).
The expression of the mouse CYP17A1 gene is epigenetically controlled.
Title: Role of DNA methylation in the tissue-specific expression of the CYP17A1 gene for steroidogenesis in rodents.
GDF-9 plays an important role in promoting preantral follicle growth by up-regulating follicular androgen biosynthesis. GDF-9 is essential for CYP17A1 expression during follicular development from the preantral to the early antral stage.
Title: Growth differentiation factor 9 promotes rat preantral follicle growth by up-regulating follicular androgen biosynthesis.
Cyp17a1 in beta-cells of rat pancreas and its local steroidogenesis are reported.
Title: Cytochrome P-450(17alpha) in beta-cells of rat pancreas and its local steroidogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Markers

RH94579 (e-PCR)
- UniSTS:119827

UniSTS:464662 (e-PCR)
- UniSTS:464662

Cyp17a1 (e-PCR), detects polymorphism
- UniSTS:464662

UniSTS:257093 (e-PCR)
- UniSTS:257093

Cyp17a1 (e-PCR), detects polymorphism
- UniSTS:257093

RH139173 (e-PCR)
- UniSTS:221259

PMC85975P1 (e-PCR)
- UniSTS:273499

Cyp17a1 (e-PCR), detects polymorphism
- UniSTS:256605

d1mgh24 (e-PCR)
- UniSTS:120250

D1Arb47 (e-PCR), detects polymorphism
- UniSTS:227016

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables steroid 17-alpha-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables steroid 17-alpha-monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables steroid 17-alpha-monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables steroid 17-alpha-monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables steroid 17-alpha-monooxygenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables steroid 17-alpha-monooxygenase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in Leydig cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in adrenal gland development	IEP Inferred from Expression Pattern more info	PubMed
involved_in androgen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in androgen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in androgen biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in biphenyl metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to antibiotic	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to gonadotropin stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in dibenzo-p-dioxin metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in glucocorticoid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glucocorticoid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in hippocampus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in hormone biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in hormone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in hormone biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in organic acid metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in phenol-containing compound metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in phthalate metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of steroid hormone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in progesterone metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in progesterone metabolic process	IEA Inferred from Electronic Annotation more info
involved_in progesterone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in progesterone metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to acetate	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cytokine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fungicide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to gonadotropin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to herbicide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insecticide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ionizing radiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to methylmercury	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to steroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in steroid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in steroid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in steroid biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in steroid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in steroid metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cell projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: steroid 17-alpha-hydroxylase/17,20 lyase

Names: 17-alpha-hydroxyprogesterone aldolase; CYPXVII; Cytochrome P450, subfamily XVII; P450-C17; P45017alpha; P450c17; cytochrome P450 17A1; cytochrome P450, subfamily 17; cytochrome P450-C17; cytochrome P450c17; steroid 17-alpha-monooxygenase

NP_036885.2

EC 1.14.14.19

EC 1.14.14.32

XP_063137365.1

EC 1.14.14.19

EC 1.14.14.32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012753.3 → NP_036885.2 steroid 17-alpha-hydroxylase/17,20 lyase

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P11715, Q68FY2, Q6LAE5

UniProtKB/TrEMBL

A0A0G2JSR8, A6JHN5

Related

ENSRNOP00000027160.2, ENSRNOT00000027160.6

Conserved Domains (1) summary

cd20673
Location:60 → 490

CYP17A1; cytochrome P450 family 17, subfamily A, polypeptide 1