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    Plaur plasminogen activator, urokinase receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 50692, updated on 27-Nov-2024

    Summary

    Official Symbol
    Plaurprovided by RGD
    Official Full Name
    plasminogen activator, urokinase receptorprovided by RGD
    Primary source
    RGD:620597
    See related
    EnsemblRapid:ENSRNOG00000037931 AllianceGenome:RGD:620597
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Par; uPAR; Plaur3; uPAR-2; uPAR-3
    Summary
    Predicted to enable enzyme binding activity; protein domain specific binding activity; and signaling receptor binding activity. Involved in several processes, including epithelial cell differentiation involved in prostate gland development; skeletal muscle tissue regeneration; and spermatogenesis. Predicted to be located in cell surface. Predicted to be part of protein complex involved in cell-matrix adhesion and serine-type endopeptidase complex. Predicted to be active in plasma membrane. Biomarker of chronic obstructive pulmonary disease; myocardial infarction; and status epilepticus. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Orthologous to human PLAUR (plasminogen activator, urokinase receptor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 29.6), Spleen (RPKM 22.6) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Plaur in Genome Data Viewer
    Location:
    1q21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (89181363..89196308)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (80053440..80068384)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (81328171..81344954)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482902 Neighboring gene immunity related GTPase cinema Neighboring gene cell adhesion molecule 4 Neighboring gene zinc finger protein 428 Neighboring gene serine/arginine repetitive matrix 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables urokinase plasminogen activator receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in epithelial cell differentiation involved in prostate gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mesenchymal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epidermal growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of homotypic cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of homotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of release of cytochrome c from mitochondria IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal muscle tissue regeneration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in spermatogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in urokinase plasminogen activator signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein complex involved in cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein complex involved in cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    part_of serine-type endopeptidase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of serine-type endopeptidase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    urokinase plasminogen activator surface receptor
    Names
    U-PAR
    plasminogen activator urokinase receptor 3
    urinary plasminogen activator receptor 2
    urinary plasminogen activator receptor 3
    urokinase plasminogen activator receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134352.2NP_599179.2  urokinase plasminogen activator surface receptor precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      O35771, P49616, P51573, Q7TN35
      UniProtKB/TrEMBL
      M0R6Z6
      Related
      ENSRNOP00000065210.4, ENSRNOT00000074985.5
      Conserved Domains (2) summary
      smart00134
      Location:214295
      LU; Ly-6 antigen / uPA receptor -like domain
      pfam00021
      Location:27101
      UPAR_LY6; u-PAR/Ly-6 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      89181363..89196308
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)