Lasp1 LIM and SH3 protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lasp1provided by RGD
Official Full Name: LIM and SH3 protein 1provided by RGD
Primary source: RGD:68408
See related: EnsemblRapid:ENSRNOG00000004132 AllianceGenome:RGD:68408
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables monoatomic ion transmembrane transporter activity. Involved in monoatomic ion transport. Located in cortical actin cytoskeleton. Is active in postsynapse. Orthologous to human LASP1 (LIM and SH3 protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 384.6), Lung (RPKM 305.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (83290820..83331989)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (82795177..82835659)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (85744662..85785130)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Up-regulated microRNA-218-5p ameliorates the damage of dopaminergic neurons in rats with Parkinson's disease via suppression of LASP1.
Title: Up-regulated microRNA-218-5p ameliorates the damage of dopaminergic neurons in rats with Parkinson's disease via suppression of LASP1.
LIM and SH3 protein 1 localizes to the leading edge of protruding lamellipodia and regulates axon development.
Title: LIM and SH3 protein 1 localizes to the leading edge of protruding lamellipodia and regulates axon development.
Lasp-1 was increased in the uterus at the time of implantation compared with the time of fertilization.
Title: Change in distribution of cytoskeleton-associated proteins, lasp-1 and palladin, during uterine receptivity in the rat endometrium.
Data indicate that Lasp-1 is a novel component of podosomes and is involved in the regulation of podosomal function.
Title: Lasp-1 regulates podosome function.
binding sites necessary for Krp1-Lasp1 interaction in vitro and function in vivo
Title: Novel beta-propeller of the BTB-Kelch protein Krp1 provides a binding site for Lasp-1 that is necessary for pseudopodial extension.
Lasp-1 is strongly expressed by central nervous system neurons and is concentrated at synaptic sites.
Title: Actin-binding proteins in a postsynaptic preparation: Lasp-1 is a component of central nervous system synapses and dendritic spines.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH133294 (e-PCR)
- UniSTS:216577

RH136366 (e-PCR)
- UniSTS:210356

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cortical actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: LIM and SH3 domain protein 1

Names: LASP-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032613.3 → NP_116002.1 LIM and SH3 domain protein 1

See identical proteins and their annotated locations for NP_116002.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q499R9, Q99MZ8

UniProtKB/TrEMBL

A0A8I6G1X8, A6HIN2

Related

ENSRNOP00000005522.6, ENSRNOT00000005522.10

Conserved Domains (3) summary

smart00227
Location:98 → 128

NEBU; The Nebulin repeat is present also in Las1

cd09447
Location:5 → 57

LIM_LASP; The LIM domain of LIM and SH3 Protein (LASP)

cd11934
Location:205 → 263

SH3_Lasp1_C; C-terminal Src Homology 3 domain of LIM and SH3 domain protein 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

83290820..83331989

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063268798.1 → XP_063124868.1 LIM and SH3 domain protein 1 isoform X1

UniProtKB/Swiss-Prot

Q499R9, Q99MZ8

UniProtKB/TrEMBL

A0A8I6G1X8, A6HIN2

Related

ENSRNOP00000098308.2, ENSRNOT00000120676.2
XM_006247288.5 → XP_006247350.1 LIM and SH3 domain protein 1 isoform X2

UniProtKB/TrEMBL

A0A8I6G1X8

Conserved Domains (3) summary

smart00227
Location:62 → 92

NEBU; The Nebulin repeat is present also in Las1

cd11934
Location:169 → 227

SH3_Lasp1_C; C-terminal Src Homology 3 domain of LIM and SH3 domain protein 1

cl02475
Location:1 → 21

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
XM_063268799.1 → XP_063124869.1 LIM and SH3 domain protein 1 isoform X3