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    Fars2 phenylalanyl-tRNA synthetase 2, mitochondrial [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306879, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Fars2provided by RGD
    Official Full Name
    phenylalanyl-tRNA synthetase 2, mitochondrialprovided by RGD
    Primary source
    RGD:1309416
    See related
    EnsemblRapid:ENSRNOG00000016135 AllianceGenome:RGD:1309416
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fars1
    Summary
    Predicted to enable phenylalanine-tRNA ligase activity and tRNA binding activity. Predicted to be involved in phenylalanyl-tRNA aminoacylation and tRNA processing. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 14 and hereditary spastic paraplegia 77. Orthologous to human FARS2 (phenylalanyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 65.0), Kidney (RPKM 50.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fars2 in Genome Data Viewer
    Location:
    17p12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (28524737..28951818, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (28319215..28746217, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (29006981..29438906, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482850 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene LYR motif containing 4 Neighboring gene Histone deacetylase 1, pseudogene 16 Neighboring gene protein phosphatase 1, regulatory subunit 3G

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A Newly Identified Missense Mutation in FARS2 Causes Autosomal-Recessive Spastic Paraplegia. Yang Y, et al. Hum Mutat, 2016 Feb. PMID 26553276
    2. Expression and characterization of a human mitochondrial phenylalanyl-tRNA synthetase. Bullard JM, et al. J Mol Biol, 1999 May 14. PMID 10329163
    3. FARS2 Deficiency Causes Cardiomyopathy by Disrupting Mitochondrial Homeostasis and the Mitochondrial Quality Control System. Li B, et al. Circulation, 2024 Apr 16. PMID 38362779, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FARS2 Deficiency Causes Cardiomyopathy by Disrupting Mitochondrial Homeostasis and the Mitochondrial Quality Control System.
      Title: FARS2 Deficiency Causes Cardiomyopathy by Disrupting Mitochondrial Homeostasis and the Mitochondrial Quality Control System.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phenylalanine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phenylalanine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phenylalanine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phenylalanine-tRNA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in phenylalanyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phenylalanyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phenylalanyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phenylalanyl-tRNA aminoacylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phenylalanine--tRNA ligase, mitochondrial
    Names
    pheRS
    phenylalanine-tRNA synthetase 1 (mitochondrial)
    phenylalanine-tRNA synthetase 2 (mitochondrial)
    phenylalanyl-tRNA synthetase, mitochondrial
    NP_001013157.1
    XP_006253885.1
    XP_006253887.1
    XP_006253888.1
    XP_038951617.1
    XP_063132461.1
    XP_063132463.1
    XP_063132464.1
    XP_063132465.1
    XP_063132466.1
    XP_063132467.1
    XP_063132468.1
    XP_063132469.1
    XP_063132470.1
    XP_063132471.1
    XP_063132473.1
    XP_063132474.1
    XP_063132475.1
    XP_063132476.1
    XP_063132477.1
    XP_063132478.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013139.1 → NP_001013157.1  phenylalanine--tRNA ligase, mitochondrial

      See identical proteins and their annotated locations for NP_001013157.1

      Status: PROVISIONAL

      Source sequence(s)
      BC078956
      UniProtKB/Swiss-Prot
      Q6AYQ3
      UniProtKB/TrEMBL
      A0A8I6AGZ1
      Related
      ENSRNOP00000021660.5, ENSRNOT00000021660.9
      Conserved Domains (3) summary
      smart00896
      Location:379 → 471
      FDX-ACB; Ferredoxin-fold anticodon binding domain
      PLN02788
      Location:29 → 471
      PLN02788; phenylalanine-tRNA synthetase
      cd00496
      Location:84 → 338
      PheRS_alpha_core; Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      28524737..28951818 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276404.1 → XP_063132474.1  phenylalanine--tRNA ligase, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A6J7D4

    2. XM_063276403.1 → XP_063132473.1  phenylalanine--tRNA ligase, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A6J7D4

    3. XM_063276405.1 → XP_063132475.1  phenylalanine--tRNA ligase, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A6J7D4

    4. XM_006253825.4 → XP_006253887.1  phenylalanine--tRNA ligase, mitochondrial isoform X3

      See identical proteins and their annotated locations for XP_006253887.1

      UniProtKB/TrEMBL
      A0A8I6AGZ1, A6J7D4
      Related
      ENSRNOP00000069318.2, ENSRNOT00000080031.3
      Conserved Domains (3) summary
      smart00896
      Location:358 → 450
      FDX-ACB; Ferredoxin-fold anticodon binding domain
      PLN02788
      Location:29 → 450
      PLN02788; phenylalanine-tRNA synthetase
      cd00496
      Location:84 → 338
      PheRS_alpha_core; Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible ...

    5. XM_063276407.1 → XP_063132477.1  phenylalanine--tRNA ligase, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A6J7D4

    6. XM_063276406.1 → XP_063132476.1  phenylalanine--tRNA ligase, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A6J7D4

    7. XM_063276401.1 → XP_063132471.1  phenylalanine--tRNA ligase, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A6J7D4

    8. XM_063276399.1 → XP_063132469.1  phenylalanine--tRNA ligase, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A0G2JV20
      Related
      ENSRNOP00000079964.2, ENSRNOT00000113971.2

    9. XM_006253823.5 → XP_006253885.1  phenylalanine--tRNA ligase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006253885.1

      UniProtKB/TrEMBL
      A0A8I5ZNT2
      Conserved Domains (3) summary
      smart00896
      Location:379 → 425
      FDX-ACB; Ferredoxin-fold anticodon binding domain
      cd00496
      Location:84 → 338
      PheRS_alpha_core; Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible ...
      TIGR00468
      Location:55 → 343
      pheS; phenylalanyl-tRNA synthetase, alpha subunit

    10. XM_063276396.1 → XP_063132466.1  phenylalanine--tRNA ligase, mitochondrial isoform X1

    11. XM_063276394.1 → XP_063132464.1  phenylalanine--tRNA ligase, mitochondrial isoform X1

    12. XM_063276393.1 → XP_063132463.1  phenylalanine--tRNA ligase, mitochondrial isoform X1

    13. XM_063276398.1 → XP_063132468.1  phenylalanine--tRNA ligase, mitochondrial isoform X1

    14. XM_063276397.1 → XP_063132467.1  phenylalanine--tRNA ligase, mitochondrial isoform X1

    15. XM_063276391.1 → XP_063132461.1  phenylalanine--tRNA ligase, mitochondrial isoform X1

    16. XM_063276395.1 → XP_063132465.1  phenylalanine--tRNA ligase, mitochondrial isoform X1

    17. XM_063276400.1 → XP_063132470.1  phenylalanine--tRNA ligase, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A0G2JV20

    18. XM_063276408.1 → XP_063132478.1  phenylalanine--tRNA ligase, mitochondrial isoform X6

    19. XM_039095689.2 → XP_038951617.1  phenylalanine--tRNA ligase, mitochondrial isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZNT2
      Conserved Domains (1) summary
      PLN02788
      Location:29 → 431
      PLN02788; phenylalanine-tRNA synthetase

    20. XM_006253826.4 → XP_006253888.1  phenylalanine--tRNA ligase, mitochondrial isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZNT2
      Conserved Domains (2) summary
      cd00496
      Location:84 → 338
      PheRS_alpha_core; Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible ...
      TIGR00468
      Location:55 → 343
      pheS; phenylalanyl-tRNA synthetase, alpha subunit

    RNA

    1. XR_010058866.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYQ3.1 GenPept UniProtKB/Swiss-Prot:Q6AYQ3

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