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    Tmcc3 transmembrane and coiled-coil domain family 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314751, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tmcc3provided by RGD
    Official Full Name
    transmembrane and coiled-coil domain family 3provided by RGD
    Primary source
    RGD:1307241
    See related
    EnsemblRapid:ENSRNOG00000007713 AllianceGenome:RGD:1307241
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307241
    Summary
    Predicted to enable 14-3-3 protein binding activity and identical protein binding activity. Predicted to be located in endoplasmic reticulum. Predicted to be active in endomembrane system. Orthologous to human TMCC3 (transmembrane and coiled-coil domain family 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 73.7), Muscle (RPKM 63.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmcc3 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (30781452..31058888)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (28893972..29171935)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (35266953..35543770)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 2, group C, member 1 Neighboring gene U4 spliceosomal RNA Neighboring gene NADH:ubiquinone oxidoreductase subunit A12 Neighboring gene uncharacterized LOC102554269 Neighboring gene uncharacterized LOC134479860 Neighboring gene 60S ribosomal protein L31-like Neighboring gene uncharacterized LOC120093558

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression and characterization of transmembrane and coiled-coil domain family 3. Sohn WJ, et al. BMB Rep, 2016 Nov. PMID 27697108, Free PMC Article
    2. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane and coiled-coil domain protein 3
    Names
    transmembrane and coiled coil domains 3
    transmembrane and coiled-coil domains protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108084.2 → NP_001101554.1  transmembrane and coiled-coil domain protein 3

      See identical proteins and their annotated locations for NP_001101554.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2K8Y7, A6IG18, D3ZLE2
      Related
      ENSRNOP00000010316.4, ENSRNOT00000010316.7
      Conserved Domains (1) summary
      pfam10267
      Location:69 → 463
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      30781452..31058888
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263459.1 → XP_063119529.1  transmembrane and coiled-coil domain protein 3 isoform X4

      UniProtKB/TrEMBL
      A6IG20

    2. XM_039079077.2 → XP_038935005.1  transmembrane and coiled-coil domain protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K8Y7, A0A8I5Y957, A6IG16
      Related
      ENSRNOP00000076849.1, ENSRNOT00000094886.2
      Conserved Domains (1) summary
      pfam10267
      Location:48 → 446
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    3. XM_039079074.2 → XP_038935002.1  transmembrane and coiled-coil domain protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K8Y7, A0A8I5Y957, A6IG16
      Conserved Domains (1) summary
      pfam10267
      Location:48 → 446
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    4. XM_063263453.1 → XP_063119523.1  transmembrane and coiled-coil domain protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y957, A6IG16

    5. XM_017594836.3 → XP_017450325.1  transmembrane and coiled-coil domain protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K8Y7, A0A8I5Y957, A6IG16
      Conserved Domains (1) summary
      pfam10267
      Location:48 → 446
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    6. XM_063263452.1 → XP_063119522.1  transmembrane and coiled-coil domain protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y957, A6IG16

    7. XM_063263450.1 → XP_063119520.1  transmembrane and coiled-coil domain protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y957, A6IG16

    8. XM_063263451.1 → XP_063119521.1  transmembrane and coiled-coil domain protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y957, A6IG16

    9. XM_063263458.1 → XP_063119528.1  transmembrane and coiled-coil domain protein 3 isoform X4

      UniProtKB/TrEMBL
      A6IG20
      Related
      ENSRNOP00000074786.2, ENSRNOT00000080291.3

    10. XM_063263456.1 → XP_063119526.1  transmembrane and coiled-coil domain protein 3 isoform X4

      UniProtKB/TrEMBL
      A6IG20

    11. XM_063263449.1 → XP_063119519.1  transmembrane and coiled-coil domain protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y957, A6IG16

    12. XM_039079073.2 → XP_038935001.1  transmembrane and coiled-coil domain protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K8Y7, A0A8I5Y957, A6IG16
      Conserved Domains (1) summary
      pfam10267
      Location:48 → 446
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    13. XM_063263447.1 → XP_063119517.1  transmembrane and coiled-coil domain protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y957, A6IG16

    14. XM_063263448.1 → XP_063119518.1  transmembrane and coiled-coil domain protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y957, A6IG16

    15. XM_017594840.3 → XP_017450329.1  transmembrane and coiled-coil domain protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K8Y7, A0A8I5Y957, A6IG16
      Conserved Domains (1) summary
      pfam10267
      Location:48 → 446
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    16. XM_039079076.2 → XP_038935004.1  transmembrane and coiled-coil domain protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K8Y7, A0A8I5Y957, A6IG16
      Conserved Domains (1) summary
      pfam10267
      Location:48 → 446
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    17. XM_039079081.2 → XP_038935009.1  transmembrane and coiled-coil domain protein 3 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K8Y7, A6IG20
      Conserved Domains (1) summary
      pfam10267
      Location:34 → 432
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    18. XM_039079079.2 → XP_038935007.1  transmembrane and coiled-coil domain protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K8Y7, A0A8I5ZPM9
      Conserved Domains (1) summary
      pfam10267
      Location:40 → 438
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    19. XM_063263455.1 → XP_063119525.1  transmembrane and coiled-coil domain protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZPM9
      Related
      ENSRNOP00000079968.1, ENSRNOT00000095728.2

    20. XM_063263454.1 → XP_063119524.1  transmembrane and coiled-coil domain protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZPM9

    21. XM_063263446.1 → XP_063119516.1  transmembrane and coiled-coil domain protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZT53
      Related
      ENSRNOP00000081540.1, ENSRNOT00000102476.2

    22. XM_006241261.5 → XP_006241323.1  transmembrane and coiled-coil domain protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K8Y7, A0A8I5ZPM9
      Conserved Domains (1) summary
      pfam10267
      Location:40 → 438
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    23. XM_063263457.1 → XP_063119527.1  transmembrane and coiled-coil domain protein 3 isoform X4

      UniProtKB/TrEMBL
      A6IG20
    Nucleotide Protein Strain
    Heading Accession and Version

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