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    Lsg1 large 60S subunit nuclear export GTPase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288029, updated on 9-Dec-2024

    Summary

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    Symbol
    Lsg1provided by RGD
    Full Name
    large 60S subunit nuclear export GTPase 1provided by RGD
    Primary source
    RGD:1309089
    See related
    EnsemblRapid:ENSRNOG00000001727 AllianceGenome:RGD:1309089
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309089
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in ribosomal subunit export from nucleus. Predicted to be located in Cajal body and endoplasmic reticulum. Predicted to be active in cytosol. Orthologous to human LSG1 (large 60S subunit nuclear export GTPase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 99.6), Kidney (RPKM 84.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lsg1 in Genome Data Viewer
    Location:
    11q22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (83648757..83673431)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (70132919..70168526)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (73693862..73723457)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549085 Neighboring gene uncharacterized LOC134481097 Neighboring gene family with sequence similarity 43, member A Neighboring gene large ribosomal subunit protein uL22-like Neighboring gene uncharacterized LOC102548792 Neighboring gene transmembrane protein 44 Neighboring gene uncharacterized LOC120095681

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human Lsg1 defines a family of essential GTPases that correlates with the evolution of compartmentalization. Reynaud EG, et al. BMC Biol, 2005 Oct 7. PMID 16209721, Free PMC Article
    2. Seven cDNAs enriched following hippocampal lesion: possible roles in neuronal responses to injury. Price M, et al. Brain Res Mol Brain Res, 2003 Sep 10. PMID 14499481
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in nuclear export IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear export ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear export ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal subunit export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Cajal body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Cajal body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    large subunit GTPase 1 homolog
    NP_001013439.1
    XP_038944038.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013421.1 → NP_001013439.1  large subunit GTPase 1 homolog

      See identical proteins and their annotated locations for NP_001013439.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091338
      UniProtKB/Swiss-Prot
      Q5BJT6
      UniProtKB/TrEMBL
      A0A8L2R9T6
      Related
      ENSRNOP00000002354.6, ENSRNOT00000002354.8
      Conserved Domains (2) summary
      cd01857
      Location:163 → 441
      HSR1_MMR1; A circularly permuted subfamily of the Ras GTPases
      COG1161
      Location:151 → 551
      RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      83648757..83673431
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088110.2 → XP_038944038.1  large subunit GTPase 1 homolog isoform X1

      UniProtKB/TrEMBL
      A6KTZ4
      Conserved Domains (2) summary
      PRK15494
      Location:334 → 453
      era; GTPase Era; Provisional
      cd01857
      Location:163 → 441
      HSR1_MMR1; A circularly permuted subfamily of the Ras GTPases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BJT6.1 GenPept UniProtKB/Swiss-Prot:Q5BJT6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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