Alg2 ALG2, alpha-1,3/1,6-mannosyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Alg2provided by RGD
Official Full Name: ALG2, alpha-1,3/1,6-mannosyltransferaseprovided by RGD
Primary source: RGD:1309940
See related: EnsemblRapid:ENSRNOG00000006369 AllianceGenome:RGD:1309940
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity and GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to act upstream of with a positive effect on protein N-linked glycosylation. Predicted to be active in cytoplasmic side of endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ii and congenital myasthenic syndrome 14. Orthologous to human ALG2 (ALG2 alpha-1,3/1,6-mannosyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 456.5), Brain (RPKM 267.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q22

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (66564328..66568887, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (61768738..61773297, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (63187466..63192025, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

RH128408 (e-PCR)
- UniSTS:211716

RH143257 (e-PCR)
- UniSTS:232504

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables alpha-1,3-mannosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-1,3-mannosyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in dolichol-linked oligosaccharide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dolichol-linked oligosaccharide biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect protein N-linked glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein glycosylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasmic side of endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: alpha-1,3/1,6-mannosyltransferase ALG2

Names: alpha-1,3-mannosyltransferase ALG2; asparagine-linked glycosylation 2 homolog (S. cerevisiae, alpha-1,3-mannosyltransferase); asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog

NP_001094180.1

EC 2.4.1.132

EC 2.4.1.257

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.