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    Susd2 sushi domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294335, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Susd2provided by RGD
    Official Full Name
    sushi domain containing 2provided by RGD
    Primary source
    RGD:1308595
    See related
    EnsemblRapid:ENSRNOG00000033389 AllianceGenome:RGD:1308595
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in negative regulation of cell cycle G1/S phase transition and negative regulation of cell division. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Orthologous to human SUSD2 (sushi domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 423.0), Spleen (RPKM 95.7) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Susd2 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (13016960..13024264)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (13017516..13024820)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (13965098..13972547)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene D-dopachrome tautomerase Neighboring gene calcineurin binding protein 1 Neighboring gene uncharacterized LOC102556116 Neighboring gene U6 spliceosomal RNA Neighboring gene gamma-glutamyltransferase 5 Neighboring gene uncharacterized LOC120098976 Neighboring gene gamma-glutamyltransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Susd2 protein regulates neurite growth and excitatory synaptic density in hippocampal cultures. Nadjar Y, et al. Mol Cell Neurosci, 2015 Mar. PMID 25724483
    2. Multiple functions of sushi domain containing 2 (SUSD2) in breast tumorigenesis. Watson AP, et al. Mol Cancer Res, 2013 Jan. PMID 23131994, Free PMC Article
    3. CSBF/C10orf99, a novel potential cytokine, inhibits colon cancer cell growth through inducing G1 arrest. Pan W, et al. Sci Rep, 2014 Oct 29. PMID 25351403, Free PMC Article
    4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Susd2 alters axon and dendritic outgrowth, regulates excitatory synapse numbers.
      Title: The Susd2 protein regulates neurite growth and excitatory synaptic density in hippocampal cultures.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC189067

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of cell cycle G1/S phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sushi domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001414913.1 → NP_001401842.1  sushi domain-containing protein 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A0G2K0Q8
      Related
      ENSRNOP00000071546.2, ENSRNOT00000079996.4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      13016960..13024264
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106381.1: Suppressed sequence

      Description
      NM_001106381.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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