Slc3a2 solute carrier family 3 member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc3a2provided by RGD
Official Full Name: solute carrier family 3 member 2provided by RGD
Primary source: RGD:3073
See related: EnsemblRapid:ENSRNOG00000018487 AllianceGenome:RGD:3073
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mdu1
Summary: Enables neutral L-amino acid transmembrane transporter activity. Involved in carboxylic acid transport; cellular response to glucose starvation; and response to muscle activity. Located in apical plasma membrane and basal plasma membrane. Biomarker of transitional cell carcinoma. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human SLC3A2 (solute carrier family 3 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 728.1), Lung (RPKM 450.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (215033601..215048064, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (205604468..205618931, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (224906566..224921029, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Taken together, these results suggest that system xc(-) plays a key role in the inflammatory reaction underlying experimental stroke.
Title: PET Imaging with [(18)F]FSPG Evidences the Role of System xc(-) on Brain Inflammation Following Cerebral Ischemia in Rats.
is concluded that the spontaneous hypertensive rat kidney overexpress LAT1/4F2hc units which display low affinity for L-leucine transport.
Title: Overexpression of non-functional LAT1/4F2hc in renal proximal tubular epithelial cells from the spontaneous hypertensive rat.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Bda49 (e-PCR)
- UniSTS:239796

RH137032 (e-PCR)
- UniSTS:219121

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-alanine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-alanine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-alanine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-leucine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-leucine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-leucine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables aromatic amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables aromatic amino acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables aromatic amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables double-stranded RNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables exogenous protein binding	IEA Inferred from Electronic Annotation more info
enables exogenous protein binding	ISO Inferred from Sequence Orthology more info
enables neutral L-amino acid transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables neutral L-amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-alanine import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-alanine import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in L-alanine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-histidine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-histidine transport	IEA Inferred from Electronic Annotation more info
involved_in L-histidine transport	ISO Inferred from Sequence Orthology more info
involved_in L-leucine import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-leucine import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in L-leucine import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in L-leucine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-leucine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-leucine transport	ISO Inferred from Sequence Orthology more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucose starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in isoleucine transport	IEA Inferred from Electronic Annotation more info
involved_in isoleucine transport	ISO Inferred from Sequence Orthology more info
involved_in methionine transport	IEA Inferred from Electronic Annotation more info
involved_in methionine transport	ISO Inferred from Sequence Orthology more info
involved_in neutral amino acid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phenylalanine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in phenylalanine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in phenylalanine transport	IEA Inferred from Electronic Annotation more info
involved_in phenylalanine transport	ISO Inferred from Sequence Orthology more info
involved_in proline transport	IEA Inferred from Electronic Annotation more info
involved_in proline transport	ISO Inferred from Sequence Orthology more info
involved_in response to exogenous dsRNA	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to exogenous dsRNA	ISO Inferred from Sequence Orthology more info
involved_in response to muscle activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info
involved_in symbiont entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone transport	IEA Inferred from Electronic Annotation more info
involved_in thyroid hormone transport	ISO Inferred from Sequence Orthology more info
involved_in tryptophan transport	IDA Inferred from Direct Assay more info	PubMed
involved_in tryptophan transport	IEA Inferred from Electronic Annotation more info
involved_in tryptophan transport	ISO Inferred from Sequence Orthology more info
involved_in tryptophan transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in tyrosine transport	IEA Inferred from Electronic Annotation more info
involved_in tyrosine transport	ISO Inferred from Sequence Orthology more info
involved_in valine transport	IEA Inferred from Electronic Annotation more info
involved_in valine transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of amino acid transport complex	IEA Inferred from Electronic Annotation more info
part_of amino acid transport complex	ISO Inferred from Sequence Orthology more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical pole of neuron	IEA Inferred from Electronic Annotation more info
located_in apical pole of neuron	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IC Inferred by Curator more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	IEA Inferred from Electronic Annotation more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: amino acid transporter heavy chain SLC3A2

Names: 4F2 cell-surface antigen heavy chain; 4F2hc; antigen identified by monoclonal antibodies 4F2; solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2; solute carrier family 3 (amino acid transporter heavy chain), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271089.2 → NP_001258018.1 amino acid transporter heavy chain SLC3A2 isoform 2

See identical proteins and their annotated locations for NP_001258018.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate segment in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q794F9

UniProtKB/TrEMBL

A6HZS2

Conserved Domains (2) summary

pfam16028
Location:42 → 118

SLC3A2_N; Solute carrier family 3 member 2 N-terminus

cl38930
Location:100 → 430

AmyAc_family; Alpha amylase catalytic domain family
NM_019283.3 → NP_062156.2 amino acid transporter heavy chain SLC3A2 isoform 1

See identical proteins and their annotated locations for NP_062156.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A0H2UHQ0, A6HZS0

Related

ENSRNOP00000025196.2, ENSRNOT00000025196.5

Conserved Domains (3) summary

COG0366
Location:159 → 514

AmyA; Glycosidase [Carbohydrate transport and metabolism]

pfam16028
Location:85 → 156

SLC3A2_N; Solute carrier family 3 member 2 N-terminus

cl07893
Location:139 → 469

AmyAc_family; Alpha amylase catalytic domain family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

215033601..215048064 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039088493.2 → XP_038944421.1 amino acid transporter heavy chain SLC3A2 isoform X1

UniProtKB/Swiss-Prot

Q794F9

UniProtKB/TrEMBL

A6HZS2

Conserved Domains (2) summary

pfam16028
Location:42 → 118

SLC3A2_N; Solute carrier family 3 member 2 N-terminus

cl38930
Location:100 → 430

AmyAc_family; Alpha amylase catalytic domain family