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    Cdc16 cell division cycle 16 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290875, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cdc16provided by RGD
    Official Full Name
    cell division cycle 16provided by RGD
    Primary source
    RGD:1305076
    See related
    EnsemblRapid:ENSRNOG00000017536 AllianceGenome:RGD:1305076
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in several processes, including anaphase-promoting complex-dependent catabolic process; positive regulation of mitotic metaphase/anaphase transition; and protein polyubiquitination. Predicted to be located in centrosome; mitotic spindle; and nucleus. Predicted to be part of anaphase-promoting complex. Predicted to be active in cytoplasm. Orthologous to human CDC16 (cell division cycle 16). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 169.0), Kidney (RPKM 128.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdc16 in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (82475234..82498797, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (75773026..75796586, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (81493355..81516493)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-like FUBI-ribosomal protein eS30 fusion protein Neighboring gene UPF3A, regulator of nonsense mediated mRNA decay Neighboring gene uncharacterized LOC120097557 Neighboring gene CFAP97 domain containing 2 Neighboring gene 5S ribosomal RNA Neighboring gene uncharacterized LOC120097558

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition. Tugendreich S, et al. Cell, 1995 Apr 21. PMID 7736578
    2. Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. Fan M, et al. Genes Dev, 2004 Feb 1. PMID 14744933, Free PMC Article
    3. APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment. Mansfeld J, et al. Nat Cell Biol, 2011 Sep 18. PMID 21926987, Free PMC Article
    4. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. Jin L, et al. Cell, 2008 May 16. PMID 18485873, Free PMC Article
    5. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. Dube P, et al. Mol Cell, 2005 Dec 22. PMID 16364912

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mitotic metaphase/anaphase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein branched polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cell division cycle protein 16 homolog
    Names
    cell division cycle 16 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024744.1 → NP_001019915.1  cell division cycle protein 16 homolog

      See identical proteins and their annotated locations for NP_001019915.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097498
      UniProtKB/TrEMBL
      A0A0G2JT88, Q4V884
      Related
      ENSRNOP00000023736.6, ENSRNOT00000023736.9
      Conserved Domains (5) summary
      COG3063
      Location:371 → 511
      PilF; Tfp pilus assembly protein PilF [Cell motility, Extracellular structures]
      TIGR02917
      Location:134 → 502
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:447 → 473
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:447 → 511
      TPR_12; Tetratricopeptide repeat
      pfam12895
      Location:15 → 94
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      82475234..82498797 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094410.2 → XP_038950338.1  cell division cycle protein 16 homolog isoform X1

      UniProtKB/TrEMBL
      A0A0G2JT88
      Conserved Domains (4) summary
      COG3063
      Location:277 → 417
      PilF; Tfp pilus assembly protein PilF [Cell motility, Extracellular structures]
      TIGR02917
      Location:40 → 408
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:353 → 379
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:353 → 417
      TPR_12; Tetratricopeptide repeat

    2. XM_063275254.1 → XP_063131324.1  cell division cycle protein 16 homolog isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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