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    YNG1 Yng1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854230, updated on 9-Dec-2024

    Summary

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    Official Symbol
    YNG1
    Official Full Name
    Yng1p
    Primary source
    SGD:S000005590
    Locus tag
    YOR064C
    See related
    AllianceGenome:SGD:S000005590; FungiDB:YOR064C; VEuPathDB:YOR064C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YOR29-15
    Summary
    Enables methylated histone binding activity. Contributes to histone acetyltransferase activity. Involved in chromatin organization and positive regulation of transcription elongation by RNA polymerase II. Part of NuA3a histone acetyltransferase complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See YNG1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (446079..446738, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ribosomal 60S subunit protein L3 Neighboring gene ubiquinol--cytochrome-c reductase catalytic subunit CYT1 Neighboring gene Msa1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular insight into interactions between the Taf14, Yng1 and Sas3 subunits of the NuA3 complex. Nguyen MC, et al. Nat Commun, 2024 Jun 24. PMID 38914563, Free PMC Article
    2. Yng1p modulates the activity of Sas3p as a component of the yeast NuA3 Hhistone acetyltransferase complex. Howe L, et al. Mol Cell Biol, 2002 Jul. PMID 12077334, Free PMC Article
    3. Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs. Taverna SD, et al. Mol Cell, 2006 Dec 8. PMID 17157260, Free PMC Article
    4. Three yeast proteins related to the human candidate tumor suppressor p33(ING1) are associated with histone acetyltransferase activities. Loewith R, et al. Mol Cell Biol, 2000 Jun. PMID 10805724, Free PMC Article
    5. ING3 is required for ATM signaling and DNA repair in response to DNA double strand breaks. Mouche A, et al. Cell Death Differ, 2019 Nov. PMID 30804473, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NuA3 HAT antagonizes the Rpd3S and Rpd3L HDACs to optimize mRNA and lncRNA expression dynamics.
      Title: NuA3 HAT antagonizes the Rpd3S and Rpd3L HDACs to optimize mRNA and lncRNA expression dynamics.
    2. The conserved yeast histone acetyltransferase complex, NuA3, specifically binds H3K4me3 through a plant homeodomain finger in the Yng1 subunit, and subsequently catalyzes the acetylation of H3K14 through the histone acetyltransferase domain of Sas3.
      Title: A PWWP domain-containing protein targets the NuA3 acetyltransferase complex via histone H3 lysine 36 trimethylation to coordinate transcriptional elongation at coding regions.
    3. These results identify a novel function for the Yng1p PHD finger in promoting stabilization of the NuA3 complex at chromatin through recognition of histone H3 lysine 4 methylation.
      Title: The Yng1p plant homeodomain finger is a methyl-histone binding module that recognizes lysine 4-methylated histone H3.
    4. Disrupting the K4me3 binding of Yng1 altered K14ac and transcription at certain genes, thereby demonstrating direct in vivo evidence of sequential trimethyl binding, acetyltransferase activity, and gene regulation by NuA3.
      Title: Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to histone acetyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methylated histone binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription elongation by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NuA3 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of NuA3 histone acetyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of NuA3a histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Yng1p
    NP_014707.1
    • Subunit of the NuA3 histone acetyltransferase complex; this complex acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3; shares significant sequence identity with the human candidate tumor suppressor p33-ING1 in C-terminal region

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      446079..446738 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183483.1 → NP_014707.1  TPA: Yng1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014707.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2C7, O00025, Q08465
      UniProtKB/TrEMBL
      A6ZNR6, B3LJB3, C7GX54, G2WMU2, N1NYB0
      Conserved Domains (1) summary
      COG5034
      Location:1 → 206
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08465.1

    Gene LinkOut

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