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    SFP1 zinc-coordinating transcription factor SFP1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851119, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SFP1
    Official Full Name
    zinc-coordinating transcription factor SFP1
    Primary source
    SGD:S000004395
    Locus tag
    YLR403W
    See related
    AllianceGenome:SGD:S000004395; FungiDB:YLR403W; VEuPathDB:YLR403W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in positive regulation of ribosomal protein gene transcription by RNA polymerase II and regulation of cell size. Located in cytoplasm and nucleus. Orthologous to human JAZF1 (JAZF zinc finger 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SFP1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (925568..927619)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene chromatin-binding protein BDF1 Neighboring gene tRNA dihydrouridine synthase DUS3 Neighboring gene seipin Neighboring gene tRNA dihydrouridine synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional response to the [ISP(+) ] prion of Saccharomyces cerevisiae differs from that induced by the deletion of its structural gene, SFP1. Drozdova P, et al. FEMS Yeast Res, 2014 Dec. PMID 25227157
    2. Reconstructing the regulatory circuit of cell fate determination in yeast mating response. Shao B, et al. PLoS Comput Biol, 2017 Jul. PMID 28742153, Free PMC Article
    3. SFP1 is involved in cell size modulation in respiro-fermentative growth conditions. Cipollina C, et al. Yeast, 2005 Apr 15. PMID 15806610
    4. Revisiting the role of yeast Sfp1 in ribosome biogenesis and cell size control: a chemostat study. Cipollina C, et al. Microbiology (Reading), 2008 Jan. PMID 18174152
    5. Sfp1 is a stress- and nutrient-sensitive regulator of ribosomal protein gene expression. Marion RM, et al. Proc Natl Acad Sci U S A, 2004 Oct 5. PMID 15353587, Free PMC Article

    See all (101) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sfp1 controls TRA1 expression, linking TORC1 and cell growth regulation to the SAGA acetyltransferase complex during misfolded protein stress.
      Title: Sfp1 links TORC1 and cell growth regulation to the yeast SAGA-complex component Tra1 in response to polyQ proteotoxicity.
    2. Sfp1 controls cell size by coordinating expression of genes implicated in mass accumulation and cell division.
      Title: Sfp1 regulates transcriptional networks driving cell growth and division through multiple promoter-binding modes.
    3. Authors propose that Sfp1p serves as a part of a regulatory complex, and the activity of this complex may be modulated differently by the absence or prionization of Sfp1p.
      Title: Transcriptional response to the [ISP(+) ] prion of Saccharomyces cerevisiae differs from that induced by the deletion of its structural gene, SFP1.
    4. we may state that SFP1 participates in the control of translation termination by means of regulation of Sup35p level
      Title: [SFP1 controls translation termination in Saccharomyces cerevisiae via regulation of the Sup35p (eRF3) level].
    5. Show that the level of SUP35 transcription in [ISP+] cells containing the sup35 mutation is increased relative to [isp-] cells and cells with a SFP1 deletion.
      Title: SUP35 expression is enhanced in yeast containing [ISP+], a prion form of the transcriptional regulator Sfp1.
    6. show that SFP1 deletion causes an irreversible [ISP(+)] loss, whereas increased SFP1 expression induces [ISP(+)] appearance.
      Title: Non-Mendelian determinant [ISP+] in yeast is a nuclear-residing prion form of the global transcriptional regulator Sfp1.
    7. Studies confirmed the promoter occupancy of RPS3 by Rap1p and other transcription factors Sfp1p, Hmo1p and Crf1p.
      Title: Determination of the core promoter regions of the Saccharomyces cerevisiae RPS3 gene.
    8. while Sfp1 is necessary for the efficient glucose-dependent regulation of ribosome biogenesis genes, it is not required for the proper induction of ribosomal protein genes in response to glucose excess
      Title: Saccharomyces cerevisiae SFP1: at the crossroads of central metabolism and ribosome biogenesis.
    9. These results suggest that Sfp1 plays a role in transcriptional and cell size control, operating at two different levels of the regulatory network linking growth, metabolism and cell size.
      Title: Revisiting the role of yeast Sfp1 in ribosome biogenesis and cell size control: a chemostat study.
    10. SFP1 is involved in cell size modulation in respiro-fermentative growth conditions.
      Title: SFP1 is involved in cell size modulation in respiro-fermentative growth conditions.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of ribosomal protein gene transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of ribosomal protein gene transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc-coordinating transcription factor SFP1
    NP_013507.1
    • Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      925568..927619
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182291.1 → NP_013507.1  TPA: zinc-coordinating transcription factor SFP1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013507.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ36, P32432
      UniProtKB/TrEMBL
      A7A1S6, C8ZE12, G2WJL6, N1NZU0
      Conserved Domains (2) summary
      COG5189
      Location:43 → 683
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:600 → 629
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32432.1

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