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    MNT3 alpha-1,3-mannosyltransferase MNT3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854801, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MNT3
    Official Full Name
    alpha-1,3-mannosyltransferase MNT3
    Primary source
    SGD:S000001276
    Locus tag
    YIL014W
    See related
    AllianceGenome:SGD:S000001276; FungiDB:YIL014W; VEuPathDB:YIL014W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables alpha-1,3-mannosyltransferase activity. Involved in protein O-linked glycosylation. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MNT3 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (326103..327995)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tRNA-Thr Neighboring gene ATP-binding cassette multidrug transporter PDR11 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mnt2p and Mnt3p of Saccharomyces cerevisiae are members of the Mnn1p family of alpha-1,3-mannosyltransferases responsible for adding the terminal mannose residues of O-linked oligosaccharides. Romero PA, et al. Glycobiology, 1999 Oct. PMID 10521541
    2. Svp26 facilitates ER exit of mannosyltransferases Mnt2 and Mnt3 in Saccharomyces cerevisiae. Tanabe Y, et al. J Gen Appl Microbiol, 2019 Sep 14. PMID 30700649
    3. Yeast Nst1 is a novel component of P-bodies and is a specific suppressor of proteasome base assembly defects. Cheng CL, et al. Mol Biol Cell, 2021 Oct 1. PMID 34347506, Free PMC Article
    4. A two-hybrid screen of the yeast proteome for Hsp90 interactors uncovers a novel Hsp90 chaperone requirement in the activity of a stress-activated mitogen-activated protein kinase, Slt2p (Mpk1p). Millson SH, et al. Eukaryot Cell, 2005 May. PMID 15879519, Free PMC Article
    5. The nucleotide sequence of Saccharomyces cerevisiae chromosome IX. Churcher C, et al. Nature, 1997 May 29. PMID 9169870

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alpha-1,3-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-1,3-mannosyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables alpha-1,3-mannosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked glycosylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1,3-mannosyltransferase MNT3
    NP_012251.3
    • Alpha-1,3-mannosyltransferase; adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      326103..327995
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179364.3 → NP_012251.3  TPA: alpha-1,3-mannosyltransferase MNT3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012251.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVR6, P40549
      UniProtKB/TrEMBL
      A6ZVQ4, B3LTM2, N1P471
      Conserved Domains (1) summary
      pfam11051
      Location:234 → 514
      Mannosyl_trans3; Mannosyltransferase putative
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40549.1

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