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    NUC1 ribonuclease [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853222, updated on 17-Dec-2024

    Summary

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    Official Symbol
    NUC1
    Official Full Name
    ribonuclease
    Primary source
    SGD:S000003744
    Locus tag
    YJL208C
    See related
    AllianceGenome:SGD:S000003744; FungiDB:YJL208C; VEuPathDB:YJL208C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables DNA endonuclease activity; DNA exonuclease activity; and RNA nuclease activity. Involved in DNA metabolic process; RNA catabolic process; and defense response to virus. Located in cytosol; mitochondrial inner membrane; and nucleus. Orthologous to human ENDOG (endonuclease G). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NUC1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (40194..41183, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene ubiquitin-protein ligase peroxin 2 Neighboring gene Cbp1p Neighboring gene Laa1p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Construction of a yeast mutant lacking the mitochondrial nuclease. Zassenhaus HP, et al. Nucleic Acids Res, 1988 Apr 25. PMID 2836791, Free PMC Article
    2. Sequence and expression of NUC1, the gene encoding the mitochondrial nuclease in Saccharomyces cerevisiae. Vincent RD, et al. Nucleic Acids Res, 1988 Apr 25. PMID 2836792, Free PMC Article
    3. Purification and properties of the major nuclease from mitochondria of Saccharomyces cerevisiae. Dake E, et al. J Biol Chem, 1988 Jun 5. PMID 3286639
    4. Yeast EndoG prevents genome instability by degrading extranuclear DNA species. Yu Y, et al. Nat Commun, 2024 Sep 3. PMID 39227600, Free PMC Article
    5. Analysis of the role of the NUC1 endo/exonuclease in yeast mitochondrial DNA recombination. Zassenhaus HP, et al. Curr Genet, 1994 Feb. PMID 8087883

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Yeast EndoG prevents genome instability by degrading extranuclear DNA species.
      Title: Yeast EndoG prevents genome instability by degrading extranuclear DNA species.
    2. In this work, we show that budding yeast executes meiotically programmed mitochondrial release of an EndoG homolog, Nuc1, during sporulation
      Title: Meiotic viral attenuation through an ancestral apoptotic pathway.
    3. FSH3 induced apoptosis of yeast in a NUC1 dependent manner.
      Title: FSH3 mediated cell death is dependent on NUC1 in Saccharomyces cerevisiae.
    4. Nuc1p can efficiently trigger apoptotic cell death when excluded from mitochondria
      Title: Endonuclease G regulates budding yeast life and death.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA nuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA endodeoxyribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in RNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in apoptotic DNA fragmentation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apoptotic DNA fragmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ribonuclease
    NP_012327.1
    • Major mitochondrial nuclease; has RNAse and DNA endo- and exonucleolytic activities; prevents genome instability by degrading extranuclear DNA sequences; roles in mitochondrial recombination, apoptosis and maintenance of polyploidy; involved in fragmentation of genomic DNA during PND (programmed nuclear destruction); role in preventing L-A mycovirus pathogenesis; encodes ortholog of mammalian endoG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      40194..41183 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181641.1 → NP_012327.1  TPA: ribonuclease [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012327.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVY6, P08466
      UniProtKB/TrEMBL
      A6ZQD1, B3LPS2, B5VKY2, C7GUE6, C8ZB12, G2WGH2, N1P323
      Conserved Domains (1) summary
      COG1864
      Location:8 → 308
      NUC1; DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08466.1

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