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    RPL37A ribosomal 60S subunit protein L37A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850882, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RPL37A
    Official Full Name
    ribosomal 60S subunit protein L37A
    Primary source
    SGD:S000004175
    Locus tag
    YLR185W
    See related
    AllianceGenome:SGD:S000004175; FungiDB:YLR185W; VEuPathDB:YLR185W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable RNA binding activity. Involved in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Part of cytosolic large ribosomal subunit and preribosome, large subunit precursor. Orthologous to human RPL37 (ribosomal protein L37). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RPL37A in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    2
    Sequence:
    Chromosome: XII; NC_001144.5 (522663..523288)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene transcriptional regulator SWI6 Neighboring gene Tos4p Neighboring gene 18S rRNA pseudouridine methyltransferase Neighboring gene Skg3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-Wide Dynamic Evaluation of the UV-Induced DNA Damage Response. Silva E, et al. G3 (Bethesda), 2020 Sep 2. PMID 32732306, Free PMC Article
    2. Growth-regulated recruitment of the essential yeast ribosomal protein gene activator Ifh1. Schawalder SB, et al. Nature, 2004 Dec 23. PMID 15616569
    3. A pharmaco-epistasis strategy reveals a new cell size controlling pathway in yeast. Moretto F, et al. Mol Syst Biol, 2013 Nov 12. PMID 24217298, Free PMC Article
    4. Overexpression of budding yeast protein phosphatase Ppz1 impairs translation. Calafí C, et al. Biochim Biophys Acta Mol Cell Res, 2020 Aug. PMID 32339526
    5. Potency of CRISPR-Cas Antifungals Is Enhanced by Cotargeting DNA Repair and Growth Regulatory Machinery at the Genetic Level. Mendoza BJ, et al. ACS Infect Dis, 2023 Dec 8. PMID 37955405, Free PMC Article

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IC
    Inferred by Curator
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of preribosome, large subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 60S subunit protein L37A
    NP_013286.1
    • Ribosomal 60S subunit protein L37A; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      522663..523288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182072.1 → NP_013286.1  TPA: ribosomal 60S subunit protein L37A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013286.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYI8, P49166
      UniProtKB/TrEMBL
      A7A175, B3RH76, C8ZDF6, G2WJ17
      Conserved Domains (1) summary
      PTZ00073
      Location:1 → 85
      PTZ00073; 60S ribosomal protein L37; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49166.2

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