FUS3 mitogen-activated serine/threonine-protein kinase FUS3 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: FUS3
Official Full Name: mitogen-activated serine/threonine-protein kinase FUS3
Primary source: SGD:S000000112
Locus tag: YBL016W
See related: AllianceGenome:SGD:S000000112; FungiDB:YBL016W; VEuPathDB:YBL016W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: DAC2
Summary: Enables MAP kinase activity. Involved in several processes, including invasive growth in response to glucose limitation; pheromone response MAPK cascade; and positive regulation of protein export from nucleus. Located in cytoplasm; mating projection tip; and nucleus. Human ortholog(s) of this gene implicated in Noonan syndrome 13; Parkinson's disease; carcinoma (multiple); melanoma; and pulmonary hypertension. Orthologous to several human genes including MAPK1 (mitogen-activated protein kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See FUS3 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (192451..193512)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fus3 and Tpk2 protein kinases regulate the phosphorylation-dependent functions of RNA helicase Dhh1 in yeast mating and Ste12 protein expression.
Title: Fus3 and Tpk2 protein kinases regulate the phosphorylation-dependent functions of RNA helicase Dhh1 in yeast mating and Ste12 protein expression.
Cla4p Kinase Activity Is Down-Regulated by Fus3p during Yeast Mating.
Title: Cla4p Kinase Activity Is Down-Regulated by Fus3p during Yeast Mating.
The pheromone response module, a mitogen-activated protein kinase pathway implicated in the regulation of fungal development, secondary metabolism and pathogenicity.
Title: The pheromone response module, a mitogen-activated protein kinase pathway implicated in the regulation of fungal development, secondary metabolism and pathogenicity.
Our work highlights Fus3 and Kss1 as important early-stage regulators of the chronological lifespan of yeast
Title: Mitogen-activated protein kinases, Fus3 and Kss1, regulate chronological lifespan in yeast.
Pheromone signaling reduces the negative effect of Kss1 while increasing the positive effect of Fus3. Negative feedback from Fus3 limits activation of Kss1.
Title: Analysis of the thresholds for transcriptional activation by the yeast MAP kinases Fus3 and Kss1.
The dual requirement for both Ste7 and this Ste5 domain in Fus3 activation explains why Fus3 is selectively activated by the mating pathway and not by other pathways that also utilize Ste7.
Title: The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation.
Peaks in Fus3 activation correlated with periodic rounds of cell morphogenesis, with each peak preceding the formation of an additional mating projection.
Title: Oscillatory phosphorylation of yeast Fus3 MAP kinase controls periodic gene expression and morphogenesis.
the mitogen-activated protein kinase Fus3 mediates fast-acting negative feedback that adjusts the dose response of the downstream system response to match the dose response of receptor-ligand binding
Title: Negative feedback that improves information transmission in yeast signalling.
Fus3 induces polarized growth in G1 phase cells by down-regulating Ste5 recruitment and by inhibiting Cln/Cdc28 kinase, which prevents basal recruitment of Ste5, Cdc42-mediated asymmetry, and mating morphogenesis.
Title: Counteractive control of polarized morphogenesis during mating by mitogen-activated protein kinase Fus3 and G1 cyclin-dependent kinase.
Fus3-triggered Tec1 degradation modulates mating transcriptional output during the pheromone response.
Title: Fus3-triggered Tec1 degradation modulates mating transcriptional output during the pheromone response.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	HDA more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in invasive growth in response to glucose limitation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of MAPK cascade	IPI Inferred from Physical Interaction more info	PubMed
involved_in pheromone response MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to pheromone triggering conjugation with cellular fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in transposable element silencing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	HDA more info	PubMed
located_in mating projection tip	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in periplasmic space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mitogen-activated serine/threonine-protein kinase FUS3

NP_009537.1

EC 2.7.11.24

Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its; inhibits recruitment of Ste5p, Cdc42p-mediated asymmetry and mating morphogenesis