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    GOR1 glyoxylate reductase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855447, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GOR1
    Official Full Name
    glyoxylate reductase
    Primary source
    SGD:S000005218
    Locus tag
    YNL274C
    See related
    AllianceGenome:SGD:S000005218; FungiDB:YNL274C; VEuPathDB:YNL274C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables glyoxylate reductase (NADH) activity. Involved in glyoxylate catabolic process. Located in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in primary hyperoxaluria and primary hyperoxaluria type 2. Orthologous to human GRHPR (glyoxylate and hydroxypyruvate reductase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GOR1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (121118..122170, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene homoserine O-acetyltransferase Neighboring gene Bor1p Neighboring gene Tof1p Neighboring gene guanine nucleotide exchange factor SEC2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ORF YNL274c (GOR1) codes for glyoxylate reductase in Saccharomyces cerevisiae. Rintala E, et al. Yeast, 2007 Feb. PMID 17173333
    2. A 13C nuclear magnetic resonance investigation of the metabolism of leucine to isoamyl alcohol in Saccharomyces cerevisiae. Dickinson JR, et al. J Biol Chem, 1997 Oct 24. PMID 9341119
    3. Ser3p (Yer081wp) and Ser33p (Yil074cp) are phosphoglycerate dehydrogenases in Saccharomyces cerevisiae. Albers E, et al. J Biol Chem, 2003 Mar 21. PMID 12525494
    4. Stereoselective, biocatalytic reductions of alpha-chloro-beta-keto esters. Kaluzna IA, et al. J Org Chem, 2005 Jan 7. PMID 15624945
    5. A Genetic Screen To Identify Genes Influencing the Secondary Redox Couple NADPH/NADP(+) in the Yeast Saccharomyces cerevisiae. Yadav S, et al. G3 (Bethesda), 2020 Jan 7. PMID 31757928, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GOR1 codes for glyoxalate reductase in Saccharomyces cerevisiae.
      Title: The ORF YNL274c (GOR1) codes for glyoxylate reductase in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glyoxylate reductase (NADH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glyoxylate reductase (NADH) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glyoxylate reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glyoxylate reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroxypyruvate reductase (NADH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroxypyruvate reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroxypyruvate reductase [NAD(P)H] activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glyoxylate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glyoxylate reductase
    NP_014125.1
    • Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      121118..122170 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183112.1 → NP_014125.1  TPA: glyoxylate reductase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014125.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0S0, P53839
      UniProtKB/TrEMBL
      A6ZRH0, B3LPB3, B5VQE0, C7GP89, C8ZGP8, G2WLJ2, N1NWX8
      Conserved Domains (1) summary
      cd12168
      Location:4 → 329
      Mand_dh_like; D-Mandelate Dehydrogenase-like dehydrogenases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53839.1

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