ATG32 mitophagy protein ATG32 [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Official Symbol: ATG32
Official Full Name: mitophagy protein ATG32
Primary source: SGD:S000001408
Locus tag: YIL146C
See related: AllianceGenome:SGD:S000001408; FungiDB:YIL146C; VEuPathDB:YIL146C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ECM37
Summary: Involved in autophagy of mitochondrion and mitochondria-nucleus signaling pathway. Located in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See ATG32 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (74184..75773, complement)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The GET pathway serves to activate Atg32-mediated mitophagy by ER targeting of the Ppg1-Far complex.
Title: The GET pathway serves to activate Atg32-mediated mitophagy by ER targeting of the Ppg1-Far complex.
Association and dissociation between the mitochondrial Far complex and Atg32 regulate mitophagy.
Title: Association and dissociation between the mitochondrial Far complex and Atg32 regulate mitophagy.
The yeast mitophagy receptor Atg32 is ubiquitinated and degraded by the proteasome.
Title: The yeast mitophagy receptor Atg32 is ubiquitinated and degraded by the proteasome.
Results reveal that a posttranslational modification discriminates a form of Atg32 targeting mitochondria for mitophagy from that, which escapes mitophagy by rapid degradation.
Title: The Degradation Pathway of the Mitophagy Receptor Atg32 Is Re-Routed by a Posttranslational Modification.
Amelioration of Atg32 expression and attenuation of Atg8-phosphatidylmonomethylethanolamine conjugation markedly rescue mitophagy in opi null cells.
Title: Phospholipid methylation controls Atg32-mediated mitophagy and Atg8 recycling.
Based on findings, authors conclude that the Tor and PpSin3-PpRpd3 pathway regulates PpAtg32 expression, but not PpAtg32 phosphorylation.
Title: Tor and the Sin3-Rpd3 complex regulate expression of the mitophagy receptor protein Atg32 in yeast.
data implicate Atg32 as a bipartite platform recruiting Atg8 and Atg11 to the mitochondrial surface and forming an initiator complex crucial for mitophagy.
Title: Autophagy-related protein 32 acts as autophagic degron and directly initiates mitophagy.
Phosphorylation of Serine 114 on Atg32 mediates mitophagy
Title: Phosphorylation of Serine 114 on Atg32 mediates mitophagy.
When mitophagy is induced, Atg32 binds to Atg11, an adaptor protein for selective autophagy.
Title: Atg32 is a tag for mitochondria degradation in yeast.
Atg32 is a transmembrane receptor that directs autophagosome formation to mitochondria.
Title: A landmark protein essential for mitophagy: Atg32 recruits the autophagic machinery to mitochondria.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in autophagy of mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondria-nucleus signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in phagophore assembly site membrane	IEA Inferred from Electronic Annotation more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
located_in vacuole	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: mitophagy protein ATG32

NP_012120.1

Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane; regulates mitophagy and ethanol production during alcoholic fermentation

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

74184..75773 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179494.1 → NP_012120.1 TPA: mitophagy protein ATG32 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012120.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A6ZVD0, B3LTZ3, B5VKG3, C7GUR3, C8ZAW6, D6VVE1, P40458

UniProtKB/TrEMBL

N1P2D6

Conserved Domains (1) summary

cd19929
Location:204 → 341

psREC_Atg32; pseudo receiver domain of autophagy receptor Atg32