NMA1 nicotinamide-nucleotide adenylyltransferase NMA1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: NMA1
Official Full Name: nicotinamide-nucleotide adenylyltransferase NMA1
Primary source: SGD:S000004320
Locus tag: YLR328W
See related: AllianceGenome:SGD:S000004320; FungiDB:YLR328W; VEuPathDB:YLR328W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables nicotinamide-nucleotide adenylyltransferase activity. Involved in NAD biosynthetic process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 9 and spondyloepiphyseal dysplasia, sensorineural hearing loss, intellectual developmental disorder, and Leber congenital amaurosis. Orthologous to several human genes including NMNAT1 (nicotinamide nucleotide adenylyltransferase 1) and NMNAT3 (nicotinamide nucleotide adenylyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See NMA1 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (784913..786118)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Salvage NAD+ biosynthetic pathway enzymes moonlight as molecular chaperones to protect against proteotoxicity.
Title: Salvage NAD+ biosynthetic pathway enzymes moonlight as molecular chaperones to protect against proteotoxicity.
N-terminal protein acetylation by NatB modulates the levels of Nmnats, the NAD(+) biosynthetic enzymes in Saccharomyces cerevisiae.
Title: N-terminal protein acetylation by NatB modulates the levels of Nmnats, the NAD(+) biosynthetic enzymes in Saccharomyces cerevisiae.
The yeast homologs of NMNAT (NMA1/2) and other genes in the NAD+ salvage pathway protect cells through a mechanism involving the targeting of toxic misfolded and oligomerized proteins for degradation and clearance.
Title: NAD+ salvage pathway proteins suppress proteotoxicity in yeast models of neurodegeneration by promoting the clearance of misfolded/oligomerized proteins.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables adenylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nicotinamide-nucleotide adenylyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nicotinamide-nucleotide adenylyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables nicotinamide-nucleotide adenylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nicotinate-nucleotide adenylyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nicotinate-nucleotide adenylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NAD biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in NAD biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in NAD biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in pyridine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nicotinamide-nucleotide adenylyltransferase NMA1

NP_013432.1

EC 2.7.7.1

EC 2.7.7.18

Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; homolog of human NMNAT; NMA1 has a paralog, NMA2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

784913..786118

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182217.1 → NP_013432.1 TPA: nicotinamide-nucleotide adenylyltransferase NMA1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013432.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VYX0, Q06178

UniProtKB/TrEMBL

A7A1L1, B3RHK3, B5VNM1, C7GUA7, C8ZDT9, N1P750

Conserved Domains (1) summary

cd09286
Location:166 → 386

NMNAT_Eukarya; Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic