YAF9 YEATS domain-containing protein YAF9 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: YAF9
Official Full Name: YEATS domain-containing protein YAF9
Primary source: SGD:S000005051
Locus tag: YNL107W
See related: AllianceGenome:SGD:S000005051; FungiDB:YNL107W; VEuPathDB:YNL107W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable histone binding activity. Involved in DNA repair and subtelomeric heterochromatin formation. Located in cytoplasm and nucleus. Part of NuA4 histone acetyltransferase complex and Swr1 complex. Orthologous to human YEATS4 (YEATS domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See YAF9 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (420098..420778)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Recognition of acetylated histone by Yaf9 regulates metabolic cycling of transcription initiation and chromatin regulatory factors.
Title: Recognition of acetylated histone by Yaf9 regulates metabolic cycling of transcription initiation and chromatin regulatory factors.
Findings show the molecular basis for the recognition of H3K27ac by a YEATS reader, and the importance of this interaction in mediating Yaf9 function within the NuA4 histone acetyltransferase complex catalytic subunit (NuA4) and chromatin-remodeling protein SWR1 (SWR1) complexes.
Title: Yaf9 subunit of the NuA4 and SWR1 complexes targets histone H3K27ac through its YEATS domain.
The cesium-specific response involved the Yaf9 protein and its activity of chromatin remodeling and transcription regulation.
Title: Cesium chloride sensing and signaling in Saccharomyces cerevisiae: an interplay among the HOG and CWI MAPK pathways and the transcription factor Yaf9.
N-terminal region of the Swr1 ATPase subunit is necessary and sufficient to direct association of Bdf1 and Swc7, as well as Arp4, Act1, Yaf9 and Swc4. This same region contains an additional H2AZ-H2B specific binding site.
Title: N terminus of Swr1 binds to histone H2AZ and provides a platform for subunit assembly in the chromatin remodeling complex.
A cell wall-restructuring process promptly occurs in response to cesium addition, which is dependent on the presence of both Hog1 and Yaf9 proteins.
Title: Role of Hog1 and Yaf9 in the transcriptional response of Saccharomyces cerevisiae to cesium chloride.
Results suggest that Yaf9p and Swc4p form a protein pair that has a role in chromatin modification with possible implications also for the function of their mammalian counterparts.
Title: Direct physical and functional interaction of the NuA4 complex components Yaf9p and Swc4p.
Yaf9 may function in NuA4 and SWR1 complexes to help antagonize silencing near telomeres
Title: The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres.
YAF9 poises the PHO5 promoter for chomatin remodeling and activation.
Title: Recruitment of the NuA4 complex poises the PHO5 promoter for chromatin remodeling and activation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in subtelomeric heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of NuA4 histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NuA4 histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of Swr1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Swr1 complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: YEATS domain-containing protein YAF9

NP_014292.3

Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes; may function to antagonize silencing near telomeres; interacts directly with Swc4p; has homology to human leukemogenic protein AF9; contains a YEATS domain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

420098..420778

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182945.3 → NP_014292.3 TPA: YEATS domain-containing protein YAF9 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014292.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W173, P53930, Q6B1N1

UniProtKB/TrEMBL

A6ZRX4, B3LNW5, B5VQT7, C7GKD6, G2WLZ8

Conserved Domains (1) summary

COG5033
Location:1 → 226

TFG3; Transcription initiation factor IIF, auxiliary subunit [Transcription]