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    PTC2 type 2C protein phosphatase PTC2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856823, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PTC2
    Official Full Name
    type 2C protein phosphatase PTC2
    Primary source
    SGD:S000000891
    Locus tag
    YER089C
    See related
    AllianceGenome:SGD:S000000891; FungiDB:YER089C; VEuPathDB:YER089C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables MAP kinase serine/threonine phosphatase activity. Involved in negative regulation of endoplasmic reticulum unfolded protein response. Located in cytoplasm and nucleus. Orthologous to human PPM1A (protein phosphatase, Mg2+/Mn2+ dependent 1A); PPM1E (protein phosphatase, Mg2+/Mn2+ dependent 1E); and PPM1N (protein phosphatase, Mg2+/Mn2+ dependent 1N (putative)). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PTC2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (335946..337340, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Arf family guanine nucleotide exchange factor SBH1 Neighboring gene Dot6p Neighboring gene anthranilate synthase TRP2 Neighboring gene 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ire1 and ptc2 genes involved in the unfolded protein response pathway in the filamentous fungus Trichoderma reesei. Valkonen M, et al. Mol Genet Genomics, 2004 Nov. PMID 15480788
    2. Bypass of Activation Loop Phosphorylation by Aspartate 836 in Activation of the Endoribonuclease Activity of Ire1. Armstrong MC, et al. Mol Cell Biol, 2017 Aug 15. PMID 28559428, Free PMC Article
    3. Rad53 regulates replication fork restart after DNA damage in Saccharomyces cerevisiae. Szyjka SJ, et al. Genes Dev, 2008 Jul 15. PMID 18628397, Free PMC Article
    4. Protein serine/threonine phosphatase Ptc2p negatively regulates the unfolded-protein response by dephosphorylating Ire1p kinase. Welihinda AA, et al. Mol Cell Biol, 1998 Apr. PMID 9528768, Free PMC Article
    5. Protein phosphatases pph3, ptc2, and ptc3 play redundant roles in DNA double-strand break repair by homologous recombination. Kim JA, et al. Mol Cell Biol, 2011 Feb. PMID 21135129, Free PMC Article

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cation binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of endoplasmic reticulum unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of endoplasmic reticulum unfolded protein response IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    type 2C protein phosphatase PTC2
    NP_011013.1
    • Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      335946..337340 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178980.1 → NP_011013.1  TPA: type 2C protein phosphatase PTC2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011013.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLZ6, P39966
      UniProtKB/TrEMBL
      A6ZR45, B3LRK7, C7GRS2, C8Z7A5, G2WCY0, N1P4Z2
      Conserved Domains (1) summary
      pfam00481
      Location:23 → 279
      PP2C; Protein phosphatase 2C
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39966.1

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