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    IFM1 translation initiation factor 2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854135, updated on 9-Dec-2024

    Summary

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    Official Symbol
    IFM1
    Official Full Name
    translation initiation factor 2
    Primary source
    SGD:S000005383
    Locus tag
    YOL023W
    See related
    AllianceGenome:SGD:S000005383; FungiDB:YOL023W; VEuPathDB:YOL023W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GTPase activity; tRNA binding activity; and translation initiation factor activity. Involved in mitochondrial translation. Located in mitochondrion. Orthologous to human MTIF2 (mitochondrial translational initiation factor 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See IFM1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (278056..280086)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Lag2p Neighboring gene uncharacterized protein Neighboring gene Tsr4p Neighboring gene tRNA-Gly

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the C2 subdomain of yeast mitochondrial initiation factor 2. Garofalo C, et al. Arch Biochem Biophys, 2005 Jul 1. PMID 15935987
    2. Purification and characterization of yeast mitochondrial initiation factor 2. Garofalo C, et al. Arch Biochem Biophys, 2003 May 15. PMID 12729623
    3. Mammalian mitochondrial initiation factor 2 supports yeast mitochondrial translation without formylated initiator tRNA. Tibbetts AS, et al. J Biol Chem, 2003 Aug 22. PMID 12799364
    4. Mitochondrial translational-initiation and elongation factors in Saccharomyces cerevisiae. Vambutas A, et al. Eur J Biochem, 1991 Nov 1. PMID 1935960
    5. Msc6p is required for mitochondrial translation initiation in the absence of formylated Met-tRNA(fMet). Franco LVR, et al. FEBS J, 2019 Apr. PMID 30767393

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    translation initiation factor 2
    NP_014619.1
    • Mitochondrial translation initiation factor 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      278056..280086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183277.1 → NP_014619.1  TPA: translation initiation factor 2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014619.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W242, P25038, Q12693
      UniProtKB/TrEMBL
      B3LJ33, C8ZHU0, N1P2T9
      Conserved Domains (2) summary
      COG0532
      Location:141 → 676
      InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]
      pfam04760
      Location:63 → 114
      IF2_N; Translation initiation factor IF-2, N-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25038.2

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