NAT1 peptide alpha-N-acetyltransferase complex A subunit NAT1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: NAT1
Official Full Name: peptide alpha-N-acetyltransferase complex A subunit NAT1
Primary source: SGD:S000002198
Locus tag: YDL040C
See related: AllianceGenome:SGD:S000002198; FungiDB:YDL040C; VEuPathDB:YDL040C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: AAA1; NAA15
Summary: Enables ribosome binding activity. Contributes to peptide alpha-N-acetyltransferase activity. Involved in N-terminal protein amino acid acetylation. Located in mitochondrion. Part of NatA complex. Used to study autism spectrum disorder; congenital heart disease; and intellectual disability. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 50. Orthologous to human NAA15 (N-alpha-acetyltransferase 15, NatA auxiliary subunit) and NAA16 (N-alpha-acetyltransferase 16, NatA auxiliary subunit). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See NAT1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (378874..381438, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structure and mechanism of acetylation by the N-terminal dual enzyme NatA/Naa50 complex has been reported.
Title: Structure and Mechanism of Acetylation by the N-Terminal Dual Enzyme NatA/Naa50 Complex.
NatA from humans and yeast have identical or nearly identical specificities
Title: Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans.
NatA null strains are specifically impaired in establishing the translation termination defect that normally accompanies Sup35 incorporation into prion complexes.
Title: The NatA acetyltransferase couples Sup35 prion complexes to the [PSI+] phenotype.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables acetyltransferase activator activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to peptide alpha-N-acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to peptide alpha-N-acetyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ribosome binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in N-terminal protein amino acid acetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in N-terminal protein amino acid acetylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of NatA complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NatA complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: peptide alpha-N-acetyltransferase complex A subunit NAT1

NP_010244.1

Subunit of protein N-terminal acetyltransferase NatA; NatA comprised of Nat1p, Ard1p, and Nat5p; N-terminally acetylates many proteins to influence multiple processes such as cell cycle progression, heat-shock resistance, mating, sporulation, telomeric silencing and early stages of mitophagy; orthologous to human NAA15; expression of both human NAA10 and NAA15 functionally complements ard1 nat1 double mutant although single mutations are not complemented by their orthologs

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

378874..381438 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180099.1 → NP_010244.1 TPA: peptide alpha-N-acetyltransferase complex A subunit NAT1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010244.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRV5, P12945

UniProtKB/TrEMBL

A6ZXT4, C8Z4N0, G2WCC0, N1PAA6

Conserved Domains (3) summary

COG4783
Location:1 → 191

YfgC; Putative Zn-dependent protease, contains TPR repeats [General function prediction only]

sd00006
Location:24 → 48

TPR; TPR repeat [structural motif]

pfam12569
Location:199 → 736

NARP1; NMDA receptor-regulated protein 1