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    AIP5 Aip5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850570, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AIP5
    Official Full Name
    Aip5p
    Primary source
    SGD:S000001912
    Locus tag
    YFR016C
    See related
    AllianceGenome:SGD:S000001912; FungiDB:YFR016C; VEuPathDB:YFR016C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Acts upstream of or within positive regulation of actin filament bundle assembly. Located in cellular bud neck and cellular bud tip. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AIP5 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (177042..180743, complement)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene calmodulin-dependent protein kinase CMK1 Neighboring gene glycogen (starch) synthase GSY1 Neighboring gene tRNA-Gly Neighboring gene Igd1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A teamwork promotion of formin-mediated actin nucleation by Bud6 and Aip5 in Saccharomyces cerevisiae. Xie Y, et al. Mol Biol Cell, 2022 Feb 1. PMID 34818061, Free PMC Article
    2. Polarisome scaffolder Spa2-mediated macromolecular condensation of Aip5 for actin polymerization. Xie Y, et al. Nat Commun, 2019 Nov 7. PMID 31699995, Free PMC Article
    3. Cell polarity protein Spa2P associates with proteins involved in actin function in Saccharomyces cerevisiae. Shih JL, et al. Mol Biol Cell, 2005 Oct. PMID 16030260, Free PMC Article
    4. Yeast Nap1-binding protein Nbp2p is required for mitotic growth at high temperatures and for cell wall integrity. Ohkuni K, et al. Genetics, 2003 Oct. PMID 14573466, Free PMC Article
    5. The cell polarity proteins Boi1 and Boi2 direct an actin nucleation complex to sites of exocytosis in Saccharomyces cerevisiae. Glomb O, et al. J Cell Sci, 2020 Feb 13. PMID 31964708

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of actin filament bundle assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud HDA PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Aip5p
    NP_116671.1
    • Protein that positively regulates actin assembly; forms a homodimer and interacts with G-actin; localization to the bud neck and bud tip requires Spa2p; YFR016C is not an essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      177042..180743 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179981.1 → NP_116671.1  TPA: Aip5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116671.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTP7, P43597
      UniProtKB/TrEMBL
      G2WDF5
      Conserved Domains (2) summary
      PTZ00121
      Location:482 → 1082
      PTZ00121; MAEBL; Provisional
      TIGR00927
      Location:271 → 528
      2A1904; K+-dependent Na+/Ca+ exchanger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43597.1

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