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    MNN5 alpha-1,2-mannosyltransferase MNN5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853253, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MNN5
    Official Full Name
    alpha-1,2-mannosyltransferase MNN5
    Primary source
    SGD:S000003722
    Locus tag
    YJL186W
    See related
    AllianceGenome:SGD:S000003722; FungiDB:YJL186W; VEuPathDB:YJL186W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables alpha-1,2-mannosyltransferase activity. Involved in protein glycosylation. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MNN5 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (80155..81915)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L39 Neighboring gene tyrosine protein kinase SWE1 Neighboring gene Atg36p Neighboring gene chromatin DNA-binding EKC/KEOPS complex subunit GON7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MNN5 encodes an iron-regulated alpha-1,2-mannosyltransferase important for protein glycosylation, cell wall integrity, morphogenesis, and virulence in Candida albicans. Bai C, et al. Eukaryot Cell, 2006 Feb. PMID 16467465, Free PMC Article
    2. Effects of mannoprotein mutations on Saccharomyces cerevisiae core oligosaccharide structure. Cohen RE, et al. J Biol Chem, 1982 May 25. PMID 6802821
    3. Side-chain structure of cell surface polysaccharide, mannan, affects hypocholesterolemic activity of yeast. Yoshida Y, et al. J Agric Food Chem, 2009 Sep 9. PMID 19670864
    4. Saccharomyces cerevisiae mannoprotein mutants. Isolation of the mnn5 mutant and comparison with the mnn3 strain. Cohen RE, et al. J Biol Chem, 1980 Aug 25. PMID 6995454
    5. Hpf2 glycan structure is critical for protection against protein haze formation in white wine. Schmidt SA, et al. J Agric Food Chem, 2009 Apr 22. PMID 19301818

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alpha-1,2-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-1,2-mannosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mannan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein mannosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1,2-mannosyltransferase MNN5
    NP_012349.2
    • Alpha-1,2-mannosyltransferase; responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      80155..81915
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181619.2 → NP_012349.2  TPA: alpha-1,2-mannosyltransferase MNN5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012349.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW04, P46982
      UniProtKB/TrEMBL
      G2WGJ0
      Conserved Domains (1) summary
      pfam11051
      Location:149 → 433
      Mannosyl_trans3; Mannosyltransferase putative
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46982.2

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