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    DPH1 2-(3-amino-3-carboxypropyl)histidine synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854703, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DPH1
    Official Full Name
    2-(3-amino-3-carboxypropyl)histidine synthase
    Primary source
    SGD:S000001365
    Locus tag
    YIL103W
    See related
    AllianceGenome:SGD:S000001365; FungiDB:YIL103W; VEuPathDB:YIL103W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable 2-(3-amino-3-carboxypropyl)histidine synthase activity; iron-sulfur cluster binding activity; and metal ion binding activity. Involved in protein histidyl modification to diphthamide. Located in cytoplasm. Used to study diphthamide deficiency syndrome. Human ortholog(s) of this gene implicated in diphthamide deficiency syndrome 1. Orthologous to human DPH1 (diphthamide biosynthesis 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DPH1 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (171751..173028)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene phosphatidylinositol 4,5-bisphosphate-binding protein Neighboring gene Hsp90 cochaperone SHQ1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional Integrity of Radical SAM Enzyme Dph1•Dph2 Requires Non-Canonical Cofactor Motifs with Tandem Cysteines. Ütkür K, et al. Biomolecules, 2024 Apr 11. PMID 38672486, Free PMC Article
    2. Substrate-Dependent Cleavage Site Selection by Unconventional Radical S-Adenosylmethionine Enzymes in Diphthamide Biosynthesis. Dong M, et al. J Am Chem Soc, 2017 Apr 26. PMID 28383907, Free PMC Article
    3. Dph3 Enables Aerobic Diphthamide Biosynthesis by Donating One Iron Atom to Transform a [3Fe-4S] to a [4Fe-4S] Cluster in Dph1-Dph2. Zhang Y, et al. J Am Chem Soc, 2021 Jun 30. PMID 34154323, Free PMC Article
    4. Dph3 is an electron donor for Dph1-Dph2 in the first step of eukaryotic diphthamide biosynthesis. Dong M, et al. J Am Chem Soc, 2014 Feb 5. PMID 24422557, Free PMC Article
    5. Structure of the Kti11/Kti13 heterodimer and its double role in modifications of tRNA and eukaryotic elongation factor 2. Glatt S, et al. Structure, 2015 Jan 6. PMID 25543256

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 2-(3-amino-3-carboxypropyl)histidine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein histidyl modification to diphthamide IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein histidyl modification to diphthamide IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein histidyl modification to diphthamide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    2-(3-amino-3-carboxypropyl)histidine synthase
    NP_012163.1
    • Protein required for synthesis of diphthamide; required along with Dph2p, Kti11p, Jjj3p, and Dph5p; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); forms a complex with Dph2p that catalyzes the first step of diphthamide biosynthesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      171751..173028
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179451.1 → NP_012163.1  TPA: 2-(3-amino-3-carboxypropyl)histidine synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012163.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVI4, P40487
      UniProtKB/TrEMBL
      B3LTV0, B5VKK7, C7GKM9, C8ZAE3, N1P4F2
      Conserved Domains (1) summary
      COG1736
      Location:69 → 421
      DPH2; Diphthamide synthase subunit DPH2 [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40487.1

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