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    CAF4 Caf4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853908, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CAF4
    Official Full Name
    Caf4p
    Primary source
    SGD:S000001744
    Locus tag
    YKR036C
    See related
    AllianceGenome:SGD:S000001744; FungiDB:YKR036C; VEuPathDB:YKR036C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in mitochondrial fission; peroxisome fission; and regulation of transcription by RNA polymerase II. Located in mitochondrion. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CAF4 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (508702..510633, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Dal80p Neighboring gene Did2p Neighboring gene Spc34p Neighboring gene tRNA N6-adenosine threonylcarbamoyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The mitochondrial fission adaptors Caf4 and Mdv1 are not functionally equivalent. Guo Q, et al. PLoS One, 2012. PMID 23300936, Free PMC Article
    2. Peroxisome fission in Hansenula polymorpha requires Mdv1 and Fis1, two proteins also involved in mitochondrial fission. Nagotu S, et al. Traffic, 2008 Sep. PMID 18513378
    3. Structural basis for recruitment of mitochondrial fission complexes by Fis1. Zhang Y, et al. Proc Natl Acad Sci U S A, 2007 Nov 20. PMID 17998537, Free PMC Article
    4. Fis1p and Caf4p, but not Mdv1p, determine the polar localization of Dnm1p clusters on the mitochondrial surface. Schauss AC, et al. J Cell Sci, 2006 Aug 1. PMID 16835275
    5. A nonproteolytic proteasome activity controls organelle fission in yeast. Hofmann L, et al. J Cell Sci, 2009 Oct 15. PMID 19773362

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. findings show that Dnm1p-dependent peroxisome fission requires Fis1p, Caf4p and Mdv1p; association of Caf4p and Mdv1p with peroxisomes relies on Fis1p
      Title: Dnm1p-dependent peroxisome fission requires Caf4p, Mdv1p and Fis1p.
    2. Mdv1p and Caf4p are molecular adaptors that recruit Dnm1p to mitochondrial fission sites.
      Title: The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria.
    3. Data suggest that Caf4p and Fis1, but not Mdv1, play a role in determining the polarized localization of those Dnm1p clusters that are not immediately involved in the mitochondrial fission process.
      Title: Fis1p and Caf4p, but not Mdv1p, determine the polar localization of Dnm1p clusters on the mitochondrial surface.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial fission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial fission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial fission IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in peroxisome fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peroxisome fission IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CCR4-NOT complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Caf4p
    NP_012962.3
    • WD40 repeat-containing protein associated with the CCR4-NOT complex; interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission; CAF4 has a paralog, MDV1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      508702..510633 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179826.2 → NP_012962.3  TPA: Caf4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012962.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZZZ8, D6VX99, P36130
      UniProtKB/TrEMBL
      C8ZCK1, G2WI66, N1P829
      Conserved Domains (3) summary
      cd00200
      Location:318 → 641
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:322 → 360
      7WD40; WD40 repeat [structural motif]
      pfam11615
      Location:65 → 124
      Caf4; CCR4-associated factor 4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36130.3

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