DYN2 dynein light chain [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: DYN2
Official Full Name: dynein light chain
Primary source: SGD:S000002832
Locus tag: YDR424C
See related: AllianceGenome:SGD:S000002832; FungiDB:YDR424C; VEuPathDB:YDR424C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SLC1
Summary: Contributes to plus-end-directed microtubule motor activity. Involved in establishment of mitotic spindle localization; nuclear migration along microtubule; and nuclear pore complex assembly. Located in cytoplasmic microtubule. Part of cytoplasmic dynein complex and peroxisomal importomer complex. Orthologous to human DYNLL1 (dynein light chain LC8-type 1) and DYNLL2 (dynein light chain LC8-type 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See DYN2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 3

Sequence:: Chromosome: IV; NC_001136.10 (1319387..1319841, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Both, Pex14p and Pex17p interact directly with Dyn2p, but in vivo, Pex17p turned out to be prerequisite for an association of Dyn2p with Pex14p.
Title: Pex17p-dependent assembly of Pex14p/Dyn2p-subcomplexes of the peroxisomal protein import machinery.
interactions of a yeast ortholog of N-IC (N-Pac11) with yeast LC8 (Dyn2) or with the intermediate chain-binding subunit of yeast dynactin (Nip100).
Title: Interactions of Yeast Dynein with Dynein Light Chain and Dynactin: GENERAL IMPLICATIONS FOR INTRINSICALLY DISORDERED DUPLEX SCAFFOLDS IN MULTIPROTEIN ASSEMBLIES.
The Dyn2-Pac11 complex promotes Dyn1 homodimerization and potentiates processivity.
Title: The yeast dynein Dyn2-Pac11 complex is a dynein dimerization/processivity factor: structural and single-molecule characterization.
Multiple recognition motifs in nucleoporin Nup159 provide a stable and rigid Nup159-Dyn2 assembly
Title: Multiple recognition motifs in nucleoporin Nup159 provide a stable and rigid Nup159-Dyn2 assembly.
Data indicate that the comparative binding of Dyn2 to two Nup159 target sites shows similar affinities (18 and 13 muM), but divergent thermal binding modes.
Title: Structure of a yeast Dyn2-Nup159 complex and molecular basis for dynein light chain-nuclear pore interaction.
Dynein-based function of Dyn2 is via its interaction with the dynein intermeadite chains; this interaction is also important for the interaction of dynein and dynactin.
Title: Functional interaction between dynein light chain and intermediate chain is required for mitotic spindle positioning.
Dynein light chain plays a role in organizing natively unfolded Phe-Gly repeats within the NPC scaffold to facilitate nucleocytoplasmic transport
Title: Molecular basis for the functional interaction of dynein light chain with the nuclear-pore complex.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables dynein intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to plus-end-directed microtubule motor activity	IGI Inferred from Genetic Interaction more info	PubMed
contributes_to plus-end-directed microtubule motor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in establishment of mitotic spindle localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in microtubule-based process	IEA Inferred from Electronic Annotation more info
involved_in nuclear migration along microtubule	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear pore complex assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nuclear pore complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear pore complex assembly	IPI Inferred from Physical Interaction more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of cytoplasmic dynein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cytoplasmic dynein complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasmic microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of dynein complex	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in nuclear periphery	HDA more info	PubMed
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of peroxisomal importomer complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dynein light chain

NP_010712.1

Cytoplasmic light chain dynein, microtubule motor protein; required for intracellular transport and cell division; involved in mitotic spindle positioning; forms complex with dynein intermediate chain Pac11p that promotes Dyn1p homodimerization, potentiates motor processivity; Dyn2p-Pac11p complex important for interaction of dynein motor complex with dynactin complex; acts as molecular glue to dimerize, stabilize Nup82-Nsp1-Nup159 complex module of cytoplasmic pore filaments

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

1319387..1319841 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180732.1 → NP_010712.1 TPA: dynein light chain [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010712.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VT54, Q02647

UniProtKB/TrEMBL

A6ZZ21, B3LFN2, C7GTN1, C8Z5Y5, G2WBG0, N1P5K5

Conserved Domains (1) summary

cd21452
Location:8 → 91

DLC-like_DYNLL1_DYNLL2; dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family