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    UGA3 Uga3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851384, updated on 9-Dec-2024

    Summary

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    Official Symbol
    UGA3
    Official Full Name
    Uga3p
    Primary source
    SGD:S000002329
    Locus tag
    YDL170W
    See related
    AllianceGenome:SGD:S000002329; FungiDB:YDL170W; VEuPathDB:YDL170W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity. Involved in gamma-aminobutyric acid catabolic process; nitrogen catabolite activation of transcription from RNA polymerase II promoter; and nitrogen utilization. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See UGA3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (156318..157904)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Par32p Neighboring gene glutamate synthase (NADH) Neighboring gene Ugx2p Neighboring gene bifunctional alcohol dehydrogenase/S-(hydroxymethyl)glutathione dehydrogenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The UGA3 gene regulating the GABA catabolic pathway in Saccharomyces cerevisiae codes for a putative zinc-finger protein acting on RNA amount. André B. Mol Gen Genet, 1990 Jan. PMID 2109179
    2. The UGA3-GLT1 intergenic region constitutes a promoter whose bidirectional nature is determined by chromatin organization in Saccharomyces cerevisiae. Ishida C, et al. Mol Microbiol, 2006 Mar. PMID 16553884
    3. Metabolomics-based systematic prediction of yeast lifespan and its application for semi-rational screening of ageing-related mutants. Yoshida R, et al. Aging Cell, 2010 Aug. PMID 20550517
    4. Binding and activation by the zinc cluster transcription factors of Saccharomyces cerevisiae. Redefining the UASGABA and its interaction with Uga3p. Idicula AM, et al. J Biol Chem, 2002 Nov 29. PMID 12235130, Free PMC Article
    5. Mutations affecting the enzymes involved in the utilization of 4-aminobutyric acid as nitrogen source by the yeast Saccharomyces cerevisiae. Ramos F, et al. Eur J Biochem, 1985 Jun 3. PMID 3888627

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Novel function of transcription factor Uga3 as an activator of branched-chain amino acid permease BAP2 gene expression.
      Title: Novel function of transcription factor Uga3 as an activator of branched-chain amino acid permease BAP2 gene expression.
    2. Uga3 and Dal81 transcription factors depend on GABA to interact with UGA genes. Dal81 is necessary for Uga3 binding to UGA promoters. Uga3 factor acts as a bridge between Dal81 and DNA.
      Title: Interplay between the transcription factors acting on the GATA- and GABA-responsive elements of Saccharomyces cerevisiae UGA promoters.
    3. Yeast zinc cluster proteins Dal81 and Uga3 cooperate by targeting common coactivators for transcriptional activation of gamma-aminobutyrate responsive genes.
      Title: Yeast zinc cluster proteins Dal81 and Uga3 cooperate by targeting common coactivators for transcriptional activation of γ-aminobutyrate responsive genes.
    4. Chromatin organization plays a major role in the bidirectional properties of the UGA3-GLT1 promoter, through the action of an upstream Abf1p-binding consensus sequence and a polydAdT(tract).
      Title: The UGA3-GLT1 intergenic region constitutes a promoter whose bidirectional nature is determined by chromatin organization in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in gamma-aminobutyric acid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nitrogen utilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Uga3p
    NP_010111.1
    • Transcriptional activator for GABA-dependent induction of GABA genes; binds to DNA elements found in the promoters of target genes and increases their expression in the presence of GABA (gamma-aminobutyrate); zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus; examples of GABA genes include UGA1, UGA2, and UGA4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      156318..157904
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180230.1 → NP_010111.1  TPA: Uga3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010111.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRI1, P26370
      UniProtKB/TrEMBL
      G2WBZ4, N1P923
      Conserved Domains (2) summary
      pfam00172
      Location:15 → 46
      Zn_clus; Fungal Zn(2)-Cys(6) binuclear cluster domain
      pfam11951
      Location:121 → 528
      Fungal_trans_2; Fungal specific transcription factor domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P26370.1

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